国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

PYGB Antibody, HRP conjugated

  • 中文名稱:
    PYGB兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA10065B0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PYGB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Brain glycogen phosphorylase antibody; Glycogen phosphorylase B antibody; Glycogen phosphorylase brain form antibody; Glycogen Phosphorylase Isoenzyme BB antibody; Glycogen phosphorylase; brain form antibody; MGC9213 antibody; Phosphorylase glycogen brain antibody; PYGB antibody; PYGB_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Glycogen phosphorylase, brain form protein (6-843AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  • 基因功能參考文獻:
    1. PYGB siRNA exerted an inhibitory effect on the cell viability of the human osteosarcoma cells MG63 and HOS by blocking the Caspase/Bcl and CDK1 signaling pathway, highlighting novel potential therapeutic methods for treating osteosarcoma. PMID: 29845265
    2. Using cysteine chemical labeling, mass spectrometry, and site-directed mutagenesis approaches, we show that thiram (and certain of its metabolites) alters the activity of bGP through the formation of an intramolecular disulfide bond (Cys(318)-Cys(326)), known to act as a redox switch that precludes the allosteric activation of bGP by AMP. PMID: 27965358
    3. disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affecting its activation by phosphorylation. This unique regulatory feature of bGP sheds new light on the isoform-specific regulation of glycogen phosphorylase and glycogen metabolism. PMID: 27660393
    4. the bGP structures reveal molecular features unique to the brain isozyme that provide a deeper understanding of the differences in the activation properties of these allosteric enzymes by the allosteric effector AMP. PMID: 27402852
    5. GPBB is a valuable biological marker to predict the prognosis in patient with acute coronary syndrome. PMID: 22818785
    6. H-FABP and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome PMID: 22838188
    7. Significant increase in plasma glycoprotein BB in patients with hypertrophic cardiomyopathy. PMID: 20482380
    8. Brain-type glycogen phosphorylase is expressed in non-small-cell lung carcinoma, particularly adenocarcinomas, and is an independent poor prognostic factor. PMID: 17393985

    顯示更多

    收起更多

  • 蛋白家族:
    Glycogen phosphorylase family
  • 數據庫鏈接:

    HGNC: 9723

    OMIM: 138550

    KEGG: hsa:5834

    STRING: 9606.ENSP00000216962

    UniGene: Hs.368157



主站蜘蛛池模板: 永州市| 井陉县| 衡阳县| 安多县| 万盛区| 漠河县| 西吉县| 土默特左旗| 富源县| 慈利县| 榆树市| 桃园市| 普宁市| 景洪市| 固安县| 治多县| 肃宁县| 永嘉县| 洪湖市| 桦甸市| 垣曲县| 黄骅市| 衡山县| 襄汾县| 体育| 大姚县| 高台县| 潮安县| 杭锦旗| 济南市| 个旧市| 邯郸市| 清丰县| 乌鲁木齐县| 西华县| 犍为县| 松潘县| 江津市| 云阳县| 武隆县| 友谊县|