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  4. PRKACB Antibody

PRKACB Antibody

  • 中文名稱：
    PRKACB兔多克隆抗體
  • 貨號：
    CSB-PA030215
  • 規(guī)格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody; cAMP-dependent protein kinase catalytic subunit beta antibody; KAPCB_HUMAN antibody; PKA C beta antibody; PKA C-beta antibody; PKACB antibody; Prkacb antibody; protein kinase A catalytic subunit beta antibody; Protein kinase cAMP dependent catalytic beta antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PKAβ cat.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA.
  • 基因功能參考文獻：
    1. Cbeta2 subunit of protein kinase A mRNA was up-regulated in prostate cancer and low expression of Cbeta2 mRNA in prostate cancer biopsies correlated with poor survival. PMID: 27838142
    2. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 PMID: 25831493
    3. The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation. PMID: 24294386
    4. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
    5. activated by podophyllotoxin PMID: 20033853
    6. PGE(2)-induced CYP1B1 expression is mediated by ligand-independent activation of the ERalpha pathway as a result of the activation of ERK, Akt, and PKA in breast cancer cells. PMID: 20093341
    7. Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed. PMID: 20086095
    8. c-MYC induces the activity of protein kinase A by inducing the transcription of the gene encoding the PKA catalytic subunit beta in multiple tissues, independent of cell proliferation by direct binding of c-MYC to promoter sequences. PMID: 12420224
    9. Data describe the identification of a variant of the beta catalytic subunit of cyclic AMP-dependent protein kinase (PKACbeta) as a p75 neurotrophin receptor(NTR)-interacting protein, which phosphorylates p75(NTR) at Ser304. PMID: 12682012
    10. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta. PMID: 14744463
    11. there is a PKA-Cbeta-mediated inhibitory mechanism of p73 function PMID: 15723830
    12. Murine lymphoid tissues express a protein that is a homologue of human protein kinase c subunit beta2 PMID: 16889664
    13. In conclusion, it seems that the Cbeta isoforms of PKA play different roles in proliferation and differentiation and could therefore be potential markers for prostate cancer progression. PMID: 16949795
    14. Data provide the first evidence that Protein kinase C -beta play pivotal role in the regulation of AA production and cellular proliferation of human monocytoid MonoMac-6 cells. PMID: 17549442
    15. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. PMID: 18499756

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  • 亞細胞定位：
    Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
  • 組織特異性：
    Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9381

    OMIM: 176892

    KEGG: hsa:5567

    STRING: 9606.ENSP00000359719

    UniGene: Hs.487325



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