PNCK Antibody

產品詳情

Uniprot No.：

Q6P2M8
基因名：

PNCK
別名：

Calcium/calmodulin dependent protein kinase type 1B antibody; Calcium/calmodulin-dependent protein kinase type 1B antibody; CaM KI beta antibody; CaM kinase I beta antibody; CaM kinase IB antibody; CaM-KI beta antibody; CaMK1b antibody; CaMKI beta antibody; CaMKI-beta antibody; EC 2.7.11.17 antibody; KCC1B_HUMAN antibody; MGC45419 antibody; PNCK antibody; Pregnancy up regulated non ubiquitously expressed CaM kinase antibody; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human CaMKIβ.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1.
基因功能參考文獻：
1. Pnck may be a marker of Trastuzumab resistance and possibly a therapeutic target in breast cancer. PMID: 25773930
2. the relationship between PNCK and prognosis in clear cell renal cell carcinoma PMID: 23634203
3. Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck. PMID: 21325639
4. Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis. PMID: 18562482
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
數據庫鏈接：

HGNC: 13415

OMIM: 300680

KEGG: hsa:139728

STRING: 9606.ENSP00000405950

UniGene: Hs.436667