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PLCD4 Antibody

  • 中文名稱:
    PLCD4兔多克隆抗體
  • 貨號(hào):
    CSB-PA866264LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA866264LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866264LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PLCD4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4 antibody; 1-phosphatidylinositol 4 antibody; 1-phosphatidylinositol-4 antibody; 5-bisphosphate phosphodiesterase delta-4 antibody; hPLCD4 antibody; MGC12837 antibody; Phosphoinositide phospholipase C delta 4 antibody; Phosphoinositide phospholipase C-delta-4 antibody; Phospholipase C delta 4 antibody; Phospholipase C-delta-4 antibody; PLC delta 4 antibody; PLC delta4 antibody; PLC-delta-4 antibody; PLCD4 antibody; PLCD4_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 protein (1-762AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,PLCD4 Antibody (CSB-PA866264LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于PLCD4 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA866264LB01HU PLCD4 Antibody, HRP conjugated ELISA
    FITC CSB-PA866264LC01HU PLCD4 Antibody, FITC conjugated
    Biotin CSB-PA866264LD01HU PLCD4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.; Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.
  • 基因功能參考文獻(xiàn):
    1. Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC). PMID: 28463110
    2. PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal PMID: 15037625
    3. Serial deletion analysis identified the core PLC-delta4 promoter region as being between -402 and -67, in which an E-box and an AP-1 binding site played important roles in the promoter activity. PMID: 17394098
  • 亞細(xì)胞定位:
    Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
  • 組織特異性:
    Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9062

    OMIM: 605939

    KEGG: hsa:84812

    STRING: 9606.ENSP00000388631

    UniGene: Hs.632528



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