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PKD1L3 Antibody, FITC conjugated

  • 中文名稱：
    PKD1L3兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA767197LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PKD1L3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PKD1L3
  • 別名：
    PKD1L3 antibody; Polycystic kidney disease protein 1-like 3 antibody; PC1-like 3 protein antibody; Polycystin-1L3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Polycystic kidney disease protein 1-like 3 protein (22-194AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
  • 基因功能參考文獻：
    1. our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. PMID: 25820328
    2. functions as a channel-forming subunit in an acid-sensing heteromeric complex formed by PKD1L3 and TRPP3 PMID: 23212381
    3. Among the three gustatory regions innervated by peripheral gustatory neurons in the geniculate ganglion, transgenic Pkd1l3 is expressed in the foliate papillae, not in the fungiform papillae or palate. PMID: 21883212
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    5. the PKD2L1-PKD1L3 complex is involved in acid sensing in vivo PMID: 20406802
    6. genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores PMID: 12782129

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Interaction with PKD2L1 is required for localization to the cell membrane.
  • 蛋白家族：
    Polycystin family
  • 組織特異性：
    Highly expressed in placenta, weakly in heart and lung.
  • 數據庫鏈接：

    HGNC: 21716

    OMIM: 607895

    KEGG: hsa:342372

    UniGene: Hs.675286