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  4. PANX3 Antibody, FITC conjugated

PANX3 Antibody, FITC conjugated

  • 中文名稱：
    PANX3兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA839402LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PANX3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PANX3
  • 別名：
    PANX3; Pannexin-3
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Pannexin-3 protein (135-215AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Structural component of the gap junctions and the hemichannels.
  • 基因功能參考文獻：
    1. Panx3 was upregulated during osteogenic differentiation in a time-dependent manner. Panx3 overexpression promoted osteogenic differentiation of human dental pulp-derived mesenchymal stromal cells, whereas depletion of Panx3 resulted in a decline of differentiation. PMID: 29241211
    2. Panx3 channels regulate the proliferation, differentiation, and fusion of skeletal muscle myoblasts. (Review) PMID: 27518505
    3. Panx3 has a defensive role in dental pulp inflammation. PMID: 27679980
    4. Case Report: osteosarcomatous transformation of axillary sweat gland neoplasm with high PANX3 expression. PMID: 27391460
    5. Panx3 hemichannel is expressed in human odontoblast-like cells and mediates ATP release into the extracellular space. PMID: 26263540
    6. Panx1 and Panx3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation. PMID: 25239622
    7. The 70 kDa immunoreactive species of Panx3 highly regulated during keratinocyte differentiation was shown to most likely correspond to another Panx3 isoform. PMID: 22947051
    8. Panx3 functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels PMID: 20404334
    9. although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules PMID: 20086016
    10. These studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels. PMID: 17925379

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Pannexin family
  • 數據庫鏈接：

    HGNC: 20573

    OMIM: 608422

    KEGG: hsa:116337

    UniGene: Hs.99235