OSBPL10 Antibody

產(chǎn)品詳情

Uniprot No.：

Q9BXB5
基因名：

OSBPL10
別名：

FLJ20363 antibody; ORP-10 antibody; ORP10 antibody; OSB10_HUMAN antibody; OSBP related protein 10 antibody; OSBP-related protein 10 antibody; OSBP9 antibody; OSBPL 10 antibody; OSBPL10 antibody; Oxysterol binding protein like 10 antibody; Oxysterol binding protein related protein 10 antibody; Oxysterol-binding protein-related protein 10 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human OSBPL10
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.
基因功能參考文獻：
1. Data indicate that the apoB-100 secretion phenotype is replicated in HepG2 cells transduced with the ORP10 shRNA lentiviruses. PMID: 22906437
2. Single-nucleotide polymorphisms in OSBPL10 is associated with peripheral arterial disease. PMID: 20610895
3. Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals to hyper-LDL cholesterolemia. PMID: 20224571
4. Analysis of variants in three genes encoding OSBP homologues in families with familial low high-density lipoprotein levels or familial combined hyperlipidemia revealed linkage of OSBPL10 single-nucleotide polymorphisms with high triglyceride trait. PMID: 19554302
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

OSBP family
數(shù)據(jù)庫鏈接：

HGNC: 16395

OMIM: 606738

KEGG: hsa:114884

STRING: 9606.ENSP00000379804

UniGene: Hs.150122