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    NSMF Antibody

    • 中文名稱:
      NSMF兔多克隆抗體
    • 貨號:
      CSB-PA015708GA01HU
    • 規(guī)格:
      ¥3,900
    • 其他:

    產(chǎn)品詳情

    • Uniprot No.:
    • 基因名:
      NSMF
    • 別名:
      Nasal embryonic LHRH factor antibody; Nasal embryonic luteinizing hormone releasing hormone factor antibody; Nasal embryonic luteinizing hormone-releasing hormone factor antibody; Nelf antibody; NELF_HUMAN antibody
    • 宿主:
      Rabbit
    • 反應(yīng)種屬:
      Human,Mouse,Rat
    • 免疫原:
      Human NELF
    • 免疫原種屬:
      Homo sapiens (Human)
    • 抗體亞型:
      IgG
    • 純化方式:
      Antigen Affinity Purified
    • 濃度:
      It differs from different batches. Please contact us to confirm it.
    • 保存緩沖液:
      PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
    • 產(chǎn)品提供形式:
      Liquid
    • 應(yīng)用范圍:
      ELISA,WB,IHC
    • Protocols:
    • 儲存條件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 貨期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    • 用途:
      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

    產(chǎn)品評價

    靶點詳情

    • 功能:
      Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
    • 基因功能參考文獻:
      1. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization. PMID: 24316376
      2. a model in which NELF recruits Pcf11 and NCoR1-GPS2-HDAC3 to paused RNAP II, reinforcing repression of HIV transcription and establishing a critical checkpoint for HIV transcription and latency. PMID: 23884411
      3. NELF is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, either singly or in combination with a mutation in another gene. PMID: 21300340
      4. our findings implicate NELF as a nuclear protein involved in the developmental function of the reproductive axis. PMID: 20025934
      5. 12% of Kallman syndrome males have KAL1 deletions, but intragenic deletions of the FGFR1, GNRH1, GNRHR, GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome. PMID: 18463157

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    • 相關(guān)疾病:
      Hypogonadotropic hypogonadism 9 with or without anosmia (HH9)
    • 亞細胞定位:
      Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Membrane.
    • 蛋白家族:
      NSMF family
    • 組織特異性:
      Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney.
    • 數(shù)據(jù)庫鏈接:

      HGNC: 29843

      OMIM: 608137

      KEGG: hsa:26012

      STRING: 9606.ENSP00000360530

      UniGene: Hs.455336