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  4. NR6A1 Antibody

NR6A1 Antibody

  • 中文名稱：
    NR6A1兔多克隆抗體
  • 貨號：
    CSB-PA016067GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GCNF 1 antibody; GCNF antibody; GCNF1 antibody; Germ cell nuclear factor antibody; hGCNF antibody; hRTR antibody; NR 61 antibody; NR61 antibody; nr6a1 antibody; NR6A1_HUMAN antibody; Nuclear receptor subfamily 6 group A member 1 antibody; Orphan nuclear receptor NR6A1 antibody; Retinoic acid receptor related testis associated receptor antibody; Retinoid receptor related testis specific receptor antibody; Retinoid receptor-related testis-specific receptor antibody; RTR antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human NR6A1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis.
  • 基因功能參考文獻：
    1. GCNF acts as a transcriptional repressor in the regulation of OCT4 gene expression through cooperative interaction with three NR binding elements in pluripotent NCCIT cells. PMID: 29057499
    2. the genes, and up-regulated 64% in undifferentiated hES cells. In addition, GCNF also showed a regulatory gene pattern that is different from RA treatment during hES cell differentiation PMID: 26769970
    3. Findings show a role for Gcnf as a regulator of iPS cell pluripotency gene expression. It also demonstrates that reactivation of the Gcnf gene may serve as a marker to distinguish completely reprogrammed iPS cells from incompletely pluripotent cells. PMID: 23495137
    4. Our results show that cellular levels of NR6A1 are correlated with disease progression in prostate cancer. PMID: 23532770
    5. These experiments confirmed that NR6A1 works as a regulator for hypocretin transcription. PMID: 21056546
    6. RTR mRNA was expressed in the human placental choriocarcinoma cell lines BeWo, JAR, and JEG-3. PMID: 11969338
    7. characterization of a novel nuclear protein, referred to as RAP80, that interacts with the retinoid-related testis-associated receptor PMID: 12080054
    8. down-regulation of CREMtau-mediated gene expression by GCNF PMID: 15456763

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR6 subfamily
  • 組織特異性：
    Shows highest expression in the germ cells of the adult testis.
  • 數據庫鏈接：

    HGNC: 7985

    OMIM: 602778

    KEGG: hsa:2649

    STRING: 9606.ENSP00000420267

    UniGene: Hs.20131



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