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NDST1 Antibody

  • 中文名稱：
    NDST1兔多克隆抗體
  • 貨號：
    CSB-PA015614LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: NDST1 antibody at 6µg/ml + MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 101, 63 kDa
      Observed band size: 85 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA015614LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA015614LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NDST1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NDST1
  • 別名：
    NDST1 antibody; HSST antibody; HSST1 antibody; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 antibody; EC 2.8.2.8 antibody; Glucosaminyl N-deacetylase/N-sulfotransferase 1 antibody; NDST-1 antibody; N-heparan sulfate sulfotransferase 1 antibody; N-HSST 1 antibody; [Heparan sulfate]-glucosamine N-sulfotransferase 1 antibody; HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 antibody; EC 3.-.-.-); Heparan sulfate N-sulfotransferase 1 antibody; EC 2.8.2.-)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 protein (40-556AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NDST1 Antibody (CSB-PA015614LA01HU)，的標記方式是Non-conjugated。對于NDST1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA015614LB01HU NDST1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015614LC01HU NDST1 Antibody, FITC conjugated
    Biotin CSB-PA015614LD01HU NDST1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan.
  • 基因功能參考文獻：
    1. Compound heterozygous mutations in NDST1 were identified, in the heparan sulfate N deacetylatase domain of one allele and the sulfotransferase domain of the other allele. This report expands the phenotypic spectrum of Ndst1 deficiency in humans. PMID: 28211985
    2. Among the genes enriched in this screening, the authors found that TM9SF2 is critical for N-sulfation of heparan sulfate and therefore for chikungunya virus infection because it is involved in the proper localization and stability of NDST1. PMID: 28404855
    3. Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development. PMID: 25125150
    4. demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures PMID: 26109066
    5. Upregulation of NDST1 is associated with chemoresistance in breast cancer. PMID: 25156775
    6. These findings establish NDST1 as a target of miR-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA PMID: 23884416
    7. MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803 PMID: 21947487
    8. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. PMID: 20129923
    9. Altered expression of NDST-1 mRNA in glomerular basement membrane in puromycin aminonucleoside nephrosis. PMID: 14966466
    10. effect of targeted inactivation of the Ndst1 gene on the inflammatory response associated with allergic inflammation PMID: 19710461
    11. the expression of the NDST-1 isoform was approximately equal at all stages of mast cell maturation PMID: 19915053

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  • 相關疾病：
    Mental retardation, autosomal recessive 46 (MRT46)
  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family, NDST subfamily
  • 組織特異性：
    Widely expressed. Expression is most abundant in heart, liver and pancreas.
  • 數據庫鏈接：

    HGNC: 7680

    OMIM: 600853

    KEGG: hsa:3340

    STRING: 9606.ENSP00000261797

    UniGene: Hs.222055