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    Msln Antibody, HRP conjugated

    • 中文名稱:
      Msln兔多克隆抗體, HRP偶聯
    • 貨號:
      CSB-PA015044LB01MO
    • 規格:
      ¥880
    • 其他:

    產品詳情

    • 產品名稱:
      Rabbit anti-Mus musculus (Mouse) Msln Polyclonal antibody
    • Uniprot No.:
    • 基因名:
    • 別名:
      Msln antibody; Mes antibody; Mpf antibody; Mesothelin antibody; Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor antibody; MPF); Mesothelin antibody; cleaved form] antibody
    • 宿主:
      Rabbit
    • 反應種屬:
      Mouse
    • 免疫原:
      Recombinant Mouse Mesothelin protein (298-600AA)
    • 免疫原種屬:
      Mus musculus (Mouse)
    • 標記方式:
      HRP
    • 克隆類型:
      Polyclonal
    • 抗體亞型:
      IgG
    • 純化方式:
      >95%, Protein G purified
    • 濃度:
      It differs from different batches. Please contact us to confirm it.
    • 保存緩沖液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    • 產品提供形式:
      Liquid
    • 應用范圍:
      ELISA
    • Protocols:
    • 儲存條件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 貨期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    • 用途:
      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

    產品評價

    靶點詳情

    • 功能:
      Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.
    • 基因功能參考文獻:
      1. our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis. PMID: 27626699
      2. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.( PMID: 28287406
      3. Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor. PMID: 26931187
      4. MSLN has an important role in the growth of lung cancer cells in vivo raising the possibility that inactivation of MPF may be a useful treatment for lung and other MSLN expressing cancers. PMID: 25118887
      5. The mesothelin expression promotes resistance to certain chemotherapy drugs such as TNF-alpha, paclitaxel, and a combination of platinum and cyclophosphamide. PMID: 22721387
      6. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion. PMID: 22371455
      7. Data show that mesothelin is a potential target in reducing resistance to cytotoxic drugs, and mesothelin-treated cells revealed rapid tyrosine phosphorylation of the p85 subunit of PI3K. PMID: 19747165
      8. binding of membrane-bound mesothelin to ovarian cancer antigen CA125 mediates heterotypic cell adhesion PMID: 14676194

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    • 亞細胞定位:
      Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; [Megakaryocyte-potentiating factor]: Secreted.
    • 蛋白家族:
      Mesothelin family
    • 組織特異性:
      Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level).
    • 數據庫鏈接:


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