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  4. MTMR4 Antibody

MTMR4 Antibody

  • 中文名稱：
    MTMR4兔多克隆抗體
  • 貨號：
    CSB-PA889148ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA889148ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA889148ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MTMR4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FYVE domain containing dual specificity protein phosphatase 2 antibody; FYVE domain-containing dual specificity protein phosphatase 2 antibody; FYVE domain-containing dual specificity protein phosphatase FYVE DSP2 antibody; FYVE-DSP2 antibody; Mtmr4 antibody; MTMR4_HUMAN antibody; Myotubularin related protein 4 antibody; Myotubularin-related protein 4 antibody; ZFYVE11 antibody; zinc finger FYVE domain containing 11 antibody; Zinc finger FYVE domain containing protein 11 antibody; Zinc finger FYVE domain-containing protein 11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Myotubularin-related protein 4 protein (570-820AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
  • 基因功能參考文獻：
    1. Here the authors demonstrate that green fluorescent protein-tagged MTMR4 is recruited to the Salmonella-containing vacuole and infection of cells depleted of endogenous MTMR4 results in a decrease in viable intracellular Salmonella. PMID: 27625994
    2. the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method PMID: 25195910
    3. MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling PMID: 23150675
    4. MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking. PMID: 20736309
    5. MTMR4 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
    6. MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes PMID: 20061380
    7. Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. PMID: 19125695

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  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性：
    Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
  • 數據庫鏈接：

    HGNC: 7452

    OMIM: 603559

    KEGG: hsa:9110

    STRING: 9606.ENSP00000325285

    UniGene: Hs.514373



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