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MT1E Antibody

  • 中文名稱：
    MT1E兔多克隆抗體
  • 貨號：
    CSB-PA17364A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA17364A0Rb at dilution of 1:100
  • 其他：

產品詳情

  • 產品描述：

    The MT1E antibody is a rabbit anti-MT1E human polyclonal antibody prepared using a synthetic polypeptide containing amino acids 4-59 of human MT1 as an immunogen. It exists as an unconjugated IgG isotype. It is only reactive with human samples. Its purity is 95%+ using protein G purified. This MT1E antibody has been validated for use in ELISA, IHC, and IF for the detection of the MT1E protein, which is highly expressed in motile cell lines and may play a role in enhancing the migration and invasion of human glioma cells.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MT1E Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MT1E
  • 別名：
    MT1E antibody; Metallothionein-1E antibody; MT-1E antibody; Metallothionein-IE antibody; MT-IE antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Metallothionein-1E protein (4-59AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MT1E Antibody (CSB-PA17364A0Rb)，的標記方式是Non-conjugated。對于MT1E Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA17364B0Rb MT1E Antibody, HRP conjugated ELISA
    FITC CSB-PA17364C0Rb MT1E Antibody, FITC conjugated
    Biotin CSB-PA17364D0Rb MT1E Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能參考文獻：
    1. Forced MT1E expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo. PMID: 28538172
    2. MT1E can enhance the migration and invasion of human glioma cells by inducing MMP-9 inactivation via the upregulation of NF-kappaB p50. PMID: 22843066
    3. Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes. PMID: 21358552
    4. MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies. PMID: 20848733
    5. Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia. PMID: 20551211
    6. Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal ion transporter activity. PMID: 15747776
    7. analysis identified genes known to be associated with cell invasion such as versican, and novel ones, including metallothionein 1E (MT1E) and nicotinamide N-methyltransferase (NNMT) PMID: 18724390
    8. High frequency of hypermethylation of MT-1E was found in endometrial carcinomas. PMID: 19420986

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  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 數據庫鏈接：

    HGNC: 7397

    OMIM: 156351

    KEGG: hsa:4493

    STRING: 9606.ENSP00000307706

    UniGene: Hs.744893