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MPC1 Antibody

  • 中文名稱：
    MPC1兔多克隆抗體
  • 貨號：
    CSB-PA206581
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COLO cells and HeLa cells, using BRP44L antibody.
    • Immunohistochemistry analysis of paraffin-embedded human heart tissue using BRP44L antibody.
    • Immunofluorescence analysis of A549 cells, using BRP44L antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MPC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human BRP44L.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mediates the uptake of pyruvate into mitochondria.
  • 基因功能參考文獻：
    1. Low MPC1 expression is associated with epithelial-mesenchymal transition in cholangiocarcinoma. PMID: 29286150
    2. Levels of lactate and mitochondrial pyruvate carrier (MPC1) mRNA were determined to scrutinize the prevalence of aerobic glycolysis..MT-RNR2 plays its anti-apoptotic role partly by avoiding deploying energy from complete oxidation of organic compounds to inorganic wastes. Thus MT-RNR2 can potentially serve as a new biomarker in the diagnosis of bladder carcinoma especially that it is present in blood circulation PMID: 28462847
    3. Low MPC1 expression is associated with prostate cancer. PMID: 26895100
    4. Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, the authors found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation. PMID: 28397687
    5. GTPBP3 plays a role in the regulation of MCP1 protein through AMPK signaling. PMID: 26642043
    6. genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier PMID: 22628558

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  • 相關(guān)疾病：
    Mitochondrial pyruvate carrier deficiency (MPYCD)
  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21606

    OMIM: 614738

    KEGG: hsa:51660

    STRING: 9606.ENSP00000354223

    UniGene: Hs.172755