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  4. MLPH Antibody

MLPH Antibody

  • 中文名稱：
    MLPH兔多克隆抗體
  • 貨號：
    CSB-PA014640LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA014640LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA014640LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Mouse kidney tissue, Mouse liver tissue
      All lanes: MLPH antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 66, 63, 53, 61, 51 kDa
      Observed band size: 66 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MLPH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MLPH
  • 別名：
    2210418F23Rik antibody; 5031433I09Rik antibody; AW228792 antibody; D1Wsu84e antibody; Exophilin 3 antibody; Exophilin-3 antibody; l(1)-3Rk antibody; l1Rk3 antibody; Leaden antibody; Leaden protein antibody; ln antibody; Melanophilin antibody; MELPH_HUMAN antibody; MGC2771 antibody; MGC59733 antibody; Mlph antibody; Slac 2a antibody; SlaC2-a antibody; Slp homolog lacking C2 domains a antibody; Synaptotagmin like protein 2a antibody; Synaptotagmin like protein lacking C2 domains A antibody; Synaptotagmin-like protein 2a antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Melanophilin protein (310-539AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MLPH Antibody (CSB-PA014640LA01HU)，的標記方式是Non-conjugated。對于MLPH Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA014640LB01HU MLPH Antibody, HRP conjugated ELISA
    FITC CSB-PA014640LC01HU MLPH Antibody, FITC conjugated
    Biotin CSB-PA014640LD01HU MLPH Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
  • 基因功能參考文獻：
    1. A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism. PMID: 27016801
    2. we detected two potential associations with well-recognized skin cancer risk traits that modify miRNA-mRNA interactions: rs2325814 in the 3'UTR of the MLPH gene and rs752107 in the 3'UTR of the WNT3A gene. PMID: 28266728
    3. These results unravel a hidden link between AR and a functional putative PCa risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH. PMID: 26411452
    4. The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin. PMID: 24584932
    5. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A. PMID: 21883982
    6. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport PMID: 11856727
    7. links rab27a and myosin Va function in melanosome transport PMID: 11980908
    8. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport. PMID: 12062444
    9. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP-bound form of Rab27A PMID: 12189142
    10. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). PMID: 12897212
    11. deletion 2q37.3 is implicated in autism PMID: 15517821
    12. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27-containing organelles in the actin-enriched cell periphery. PMID: 12221080
    13. Slac2-a/melanophilin contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slac2-a specifically and directly binds the GTP-bound form of Rab27A and Rab27B (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va. PMID: 11856727

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  • 相關疾病：
    Griscelli syndrome 3 (GS3)
  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 29643

    OMIM: 606526

    KEGG: hsa:79083

    STRING: 9606.ENSP00000264605

    UniGene: Hs.102406



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