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    4. MLF1 Antibody

    MLF1 Antibody

    • 中文名稱：
      MLF1兔多克隆抗體
    • 貨號(hào)：
      CSB-PA014621ESR1HU
    • 規(guī)格：
      ￥440
    • 圖片：
      • Western blot
        All lanes: MLF1 antibody at 4.05μg/ml + Mouse brain tissue
        Secondary
        Goat polyclonal to rabbit IgG at 1/10000 dilution
        Predicted band size: 31, 24, 34, 28, 30 kDa
        Observed band size: 31 kDa
      • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA014621ESR1HU at dilution of 1:100
      • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA014621ESR1HU at dilution of 1:100
    • 其他：

    產(chǎn)品詳情

    • 產(chǎn)品名稱：
      Rabbit anti-Homo sapiens (Human) MLF1 Polyclonal antibody
    • Uniprot No.：
    • 基因名：
      MLF1
    • 別名：
      Hls7 antibody; MLF1 antibody; MLF1_HUMAN antibody; Myelodysplasia myeloid leukemia factor 1 antibody; Myelodysplasia-myeloid leukemia factor 1 antibody; Myeloid leukemia factor 1 antibody; myeloid leukemia factor 1 variant 1 antibody; myeloid leukemia factor 1 variant 2 antibody; myeloid leukemia factor 1 variant 3 antibody
    • 宿主：
      Rabbit
    • 反應(yīng)種屬：
      Human, Mouse
    • 免疫原：
      Recombinant Human Myeloid leukemia factor 1 protein (1-268AA)
    • 免疫原種屬：
      Homo sapiens (Human)
    • 標(biāo)記方式：
      Non-conjugated
    • 克隆類(lèi)型：
      Polyclonal
    • 抗體亞型：
      IgG
    • 純化方式：
      Antigen Affinity Purified
    • 濃度：
      It differs from different batches. Please contact us to confirm it.
    • 保存緩沖液：
      PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    • 產(chǎn)品提供形式：
      Liquid
    • 應(yīng)用范圍：
      ELISA, WB, IHC
    • 推薦稀釋比：
      Application Recommended Dilution
      WB 1:1000-1:5000
      IHC 1:20-1:200
    • Protocols：
    • 儲(chǔ)存條件：
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 貨期：
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    • 用途：
      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

    產(chǎn)品評(píng)價(jià)

    靶點(diǎn)詳情

    • 功能：
      Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
    • 基因功能參考文獻(xiàn)：
      1. Mutation in HTT causes Huntington's disease (HD); aggregates of mutated HTT cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT; MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT aggregates and subsequent apoptosis. (HTT = Huntingtin protein; MLF = myeloid leukemia factor) PMID: 27840155
      2. The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival. PMID: 28137643
      3. These findings suggest that MLF and the associated co-chaperones play a direct role in modulating gene transcription. PMID: 27984043
      4. SNP associated with neuroblastoma resides upstream of the MLF1. Gene silencing of MLF1 in neuroblastoma cells results in significant growth inhibition. PMID: 28545128
      5. Data indicte that acute myeloid leukemia (AML) with NPM1-MLF1 and AML with NPM1 mutations showed similar immunophenotypical and molecular features, including gene mutation patterns and gene expression profiling (GEP). PMID: 23403313
      6. The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent. PMID: 23271436
      7. changes in the subcellular localization of NPM, due to alterations in the relative abundance of NPM and NPM-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm +/- cells PMID: 22193965
      8. Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry. PMID: 22151054
      9. MLF1 gene rearrangement is associated with acute myeloid leukemia. PMID: 20471513
      10. phosphorylation of 14-3-3 binding site by MADM PMID: 12176995
      11. These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia, and that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease PMID: 14506644
      12. Over-expression of MLF1 has little impact on skeletal muscle function in mice; progressive formation of protein aggregates in muscle are not necessarily pathogenic; MLF1 and MRJ may function together to ameliorate the toxic effects of mutant proteins. PMID: 17854834
      13. shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation PMID: 17967869

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    • 相關(guān)疾?。?/div>
      A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
    • 亞細(xì)胞定位：
      Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.
    • 蛋白家族：
      MLF family
    • 組織特異性：
      Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
    • 數(shù)據(jù)庫(kù)鏈接：

      HGNC: 7125

      OMIM: 601402

      KEGG: hsa:4291

      UniGene: Hs.85195