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  4. LSM14A Antibody

LSM14A Antibody

  • 中文名稱：
    LSM14A兔多克隆抗體
  • 貨號：
    CSB-PA013203GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    LSM14A
  • 別名：
    AlphaSNBP antibody; C19orf13 antibody; Chromosome 19 open reading frame 13 antibody; DKFZp434D1335 antibody; FAM61A antibody; Family with sequence similarity 61 member A antibody; hRAP55 antibody; hRAP55A antibody; LS14A_HUMAN antibody; LSM14 homolog A (SCD6 S cerevisiae) antibody; LSM14 homolog A antibody; LSM14A antibody; Protein FAM61A antibody; Protein LSM14 homolog A antibody; Protein SCD6 homolog antibody; Putative alpha synuclein binding protein antibody; Putative alpha-synuclein-binding protein antibody; RAP55 antibody; RNA associated protein 55 antibody; RNA-associated protein 55A antibody; SCD6 homolog A (S cerevisiae) antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human LSM14A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
  • 基因功能參考文獻：
    1. alpha-synuclein p.A53V homozygous mutation leads to a distinct phenotype of progressive parkinsonism and cognitive decline, commonly observed in patients with SNCA missense mutation or multiplications PMID: 28666710
    2. Excessive iron and alpha-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress. PMID: 26940028
    3. RAP55/LSM14 binds directly the tubulin and that is implicated in the process of the mitotic spindle stabilization PMID: 26339800
    4. RAP55 is important for the assembly of cytoplasmic mRNP granules and that PRMT1 is required for RAP55A to localize to P-bodies. PMID: 22614839
    5. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. PMID: 22973032
    6. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. PMID: 22745163
    7. this protein family has evolved a common and fundamental role in the control of mRNA translation. Human RAP55A is an autoantigen detected in the serum of patients with primary biliary cirrhosis (PBC). PMID: 18723115

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  • 亞細胞定位：
    Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule.
  • 蛋白家族：
    LSM14 family
  • 數據庫鏈接：

    HGNC: 24489

    OMIM: 610677

    KEGG: hsa:26065

    STRING: 9606.ENSP00000413964

    UniGene: Hs.744009