国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

LRRC8D Antibody

  • 中文名稱:
    LRRC8D兔多克隆抗體
  • 貨號:
    CSB-PA013171GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    LRRC8D
  • 別名:
    LRRC8D antibody; LRRC5 antibody; UNQ213/PRO239 antibody; Volume-regulated anion channel subunit LRRC8D antibody; Leucine-rich repeat-containing protein 5 antibody; Leucine-rich repeat-containing protein 8D antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human LRRC8D
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion. VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Mediates the import of the antibiotic blasticidin-S into the cell.
  • 基因功能參考文獻:
    1. LRRC8D is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    2. identified four genes, named TA-LRRP, AD158, LRRC5, and FLJ23420, as unknown LRRC8-like genes PMID: 15094057
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    LRRC8 family
  • 數據庫鏈接:

    HGNC: 16992

    OMIM: 612890

    KEGG: hsa:55144

    STRING: 9606.ENSP00000338887

    UniGene: Hs.482087



主站蜘蛛池模板: 和平区| 泉州市| 明光市| 大洼县| 榆中县| 清苑县| 蒙城县| 扶风县| 玉林市| 甘泉县| 东源县| 兴国县| 璧山县| 达孜县| 安吉县| 科尔| 辽宁省| 洛阳市| 大安市| 诏安县| 成都市| 襄城县| 鹤壁市| 廉江市| 息烽县| 蒙城县| 苗栗市| 云梦县| 井冈山市| 牟定县| 房产| 稻城县| 达拉特旗| 临泉县| 县级市| 越西县| 开封县| 饶平县| 南华县| 苍南县| 临颍县|