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  4. LGR6 Antibody

LGR6 Antibody

  • 中文名稱：
    LGR6兔多克隆抗體
  • 貨號：
    CSB-PA003149
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using LGR6 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ14471 antibody; Gonadotropin receptor antibody; GPCR antibody; Leucine rich repeat containing G protein coupled receptor 6 antibody; Leucine-rich repeat-containing G-protein coupled receptor 6 antibody; Lgr6 antibody; LGR6_HUMAN antibody; VTS20631 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human LGR6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
  • 基因功能參考文獻：
    1. Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro. PMID: 29625528
    2. Lgr6 has a tumorpromoting role in the development of colorectal cancer. PMID: 29693156
    3. Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. PMID: 27798604
    4. Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6. PMID: 28013222
    5. LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    6. Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration. PMID: 22615920

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數據庫鏈接：

    HGNC: 19719

    OMIM: 606653

    KEGG: hsa:59352

    STRING: 9606.ENSP00000356247

    UniGene: Hs.497402



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