The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA061951(IL2RB Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA061951(IL2RB Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 231 cells, 293T cells, Raji cells, hela cells, Primary antibody: CSB-PA061951(IL2RB Antibody) at dilution 1/325, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
基因功能參考文獻:
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported. PMID: 27463037
An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA positive Rheumatoid arthritis patients. PMID: 26203933
CD112 downregulation resulted in a reduced ability of DNAM-1 to bind to the surface of both virus-infected and gD-transfected cells. PMID: 25352670
IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis. PMID: 24648606
in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes. PMID: 24200909
This is the first report demonstrating that heterodimeric combinations of IL-2R and IL-6R subunits are functional for signaling. PMID: 23926072
MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the Ewing Sarcoma gene, but was found to be neutral related to EWS in a case-control study analyzing allele frequencies and linkage disequilibrium. PMID: 24112992
Suggest that oxalate-induced activation of the renal IL-2Rbeta pathway may lead to a plethora of cellular changes, the most common of which is the induction of inflammation. PMID: 24523387
Data indicate that both CgammaCR-CD127(+)composed of Interleukin-7 (IL-7) tethered to IL-7Ralpha/CD127, and CgammaCR-CD122(+) CD8(+) T((E/CM)) engraft in mice and persist in an absence of exogenous cytokine administration. PMID: 23628622
Data suggest that cross-talk occurs between cAMP/PKA and the IL-2R beta/Jak3/Stat5b cascade in T-cells. PMID: 23341462
Single nucleotide polymorphism in IL2RB is associated with lung cancer. PMID: 22573796
The researchers found evidence that there were significant differences between the D22S1045 locus in the Maghreb population and other populations. PMID: 21674833
Genetic variants of IL2RB may be associated with the development of acute rejection episodes and may help predict risk in kidney transplantation patients. PMID: 21839273
LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the beta subunit of the IL-2 receptor. PMID: 21865161
Lyn coimmunoprecipitates with the interleukin-2 beta receptor and JAK3 proteins in human T-cell leukemia virus type 1-infected T-cells. PMID: 21345943
IL-15R alpha, which bears most of the binding affinity for IL-15, behaves as a potent IL-15 agonist by enhancing its binding and biological effects through the IL-15R beta/gamma heterodimer. PMID: 16284400
Data show that co-expression of ZNF300 and Egr1 lead to enhanced IL-2Rbeta promoter activity, and suggest that ZNF300 is another regulator of the human IL-2Rbeta promoter. PMID: 20585888
IL-2Rbeta is subject to ectodomain shedding generating an intracellular fragment biologically functional, because (i) it is phosphorylated, (ii) it associates with STAT5A, and (iii) it increases cell proliferation. PMID: 20495002
Alternate signalling pathways from the interleukin-2 receptor PMID: 11750878
Here we show, in four cell lines of human adult T cell lymphoma/leukemia origin, that the three IL-2R subunits are compartmented together with HLA glycoproteins and CD48 molecules in the plasma membrane PMID: 11856346
SHB links IL2 receptor for signal transduction and mediates apoptosis PMID: 12200137
Peptide p1-30, which is composed of the 30 amino-terminal residues of human interleukin-2, binds as a tetramer to the dimeric IL-2Rbeta2 receptor PMID: 12676936
The development of breast tumour is associated with an increased expression of IL-2 receptor beta and this expression also seems to be associated with the malignancy of the tumour. PMID: 14680494
Cultures in the presence of peptide epitopes to this receptor inhibited T cell proliferation. PMID: 15350462
Interleukin-2 receptor beta-627*C homozygote and C allele correlate with higher susceptibility to endometriosis. PMID: 16084898
location of the G245R polymorphism next to the proximal cytokine receptor homology segment; suggestive of a genetic association with the development of visceral leishmaniasis. PMID: 17108990
these results indicate that precise sorting of IL-2Rbeta from early to late endosomes is mediated by Hrs, a known sorting component of the ubiquitin-dependent machinery, in a manner that is independent of UIM-ubiquitin binding PMID: 18445679
study found PI3K & STAT5 signaling pathways are required for granulysin expression & IL-2Rbeta induction & IL-2Rbeta induction is a prerequisite for granulysin expression; both signaling pathways are defective in CD4+ T cells from HIV-infected patients PMID: 18490721
Report the selective expansion of genetically modified T cells using an antibody/IL2RB receptor chimera. PMID: 18589435
High serum IL-2R level is associated with peripheral T-cell lymphoma, unspecified. PMID: 18592269
The uncleaved 12-kDa form of p12(I) resides in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), the heavy chain of the major histocompatibility complex (MHC) class I, as well as calreticulin and calnexin. PMID: 18791162
the preformed complexes between gamma c and IL-2Rbeta or IL-9Ralpha promote signaling by the JAK3 A572V mutant without ligand, identified in several human cancers. PMID: 18829468
The C627T polymorphism in the IL2RB gene is not associated with risk of endometriosis in Korean women. PMID: 19602517
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亞細胞定位:
Cell membrane; Single-pass type I membrane protein.