国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

IGHM Antibody

  • 中文名稱:
    IGHM兔多克隆抗體
  • 貨號:
    CSB-PA582625
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HEPG2 cells using IgM Chain C Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    IGHM
  • 別名:
    IGHMImmunoglobulin heavy constant mu antibody; Ig mu chain C region antibody; Ig mu chain C region BOT antibody; Ig mu chain C region GAL antibody; Ig mu chain C region OU antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from IgM Chain C at AA range: 391-440
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
  • 相關疾病:
    Agammaglobulinemia 1, autosomal recessive (AGM1)
  • 亞細胞定位:
    [Isoform 1]: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
  • 數據庫鏈接:

    HGNC: 5541

    OMIM: 147020

    UniGene: Hs.510635



主站蜘蛛池模板: 临沂市| 丰都县| 柘荣县| 梁山县| 邯郸市| 南昌市| 行唐县| 衡南县| 布拖县| 蒙山县| 新建县| 江津市| 鹤岗市| 焦作市| 历史| 明光市| 临邑县| 武陟县| 美姑县| 高州市| 和龙市| 闽清县| 阳谷县| 新平| 荣昌县| 吉安市| 巴楚县| 阳朔县| 赤水市| 阿鲁科尔沁旗| 巴里| 抚州市| 汉寿县| 曲靖市| 石屏县| 拉孜县| 广西| 湘西| 牙克石市| 鄱阳县| 新宁县|