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HOMER3 Antibody

  • 中文名稱：
    HOMER3兔多克隆抗體
  • 貨號：
    CSB-PA878880LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: HOMER3 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 17, 14, 36 kDa
      Observed band size: 40 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA878880LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HOMER3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    HOME3_HUMAN antibody; HOMER 3 antibody; Homer 3D protein antibody; Homer homolog 3 (Drosophila) antibody; Homer neuronal immediate early gene 3 antibody; Homer protein homolog 3 antibody; Homer-3 antibody; Homer3 antibody; VESL3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Homer protein homolog 3 protein (151-361AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，HOMER3 Antibody (CSB-PA878880LA01HU)，的標記方式是Non-conjugated。對于HOMER3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA878880LB01HU HOMER3 Antibody, HRP conjugated ELISA
    FITC CSB-PA878880LC01HU HOMER3 Antibody, FITC conjugated
    Biotin CSB-PA878880LD01HU HOMER3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
  • 基因功能參考文獻：
    1. Homer3 acts as a scaffold that spatially organizes actin assembly to support neutrophil polarity and motility downstream of GPCR activation. PMID: 25739453
    2. Interaction of the protein with amyloid precursor protein is regulated by calcium homeostasis. PMID: 24792907
    3. Loss of Homer3 is associated with acute myeloid leukemia. PMID: 23725168
    4. Homer3 specifically associates with a novel ubiquitin-like domain in the I kappa B kinase (IKK) beta subunit of the IKK complex. PMID: 20693425
    5. Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta. PMID: 14645007
    6. Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells PMID: 16979624
    7. study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin PMID: 18218901

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  • 亞細胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    Homer family
  • 數據庫鏈接：

    HGNC: 17514

    OMIM: 604800

    KEGG: hsa:9454

    STRING: 9606.ENSP00000376162

    UniGene: Hs.720208