国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

GGH Antibody, FITC conjugated

  • 中文名稱:
    GGH兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA009389LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GGH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Conjugase antibody; folylpolygammaglutamyl hydrolase antibody; gamma glutamyl hydrolase antibody; Gamma-Glu-X carboxypeptidase antibody; Gamma-glutamyl hydrolase (conjugase; folylpolygammaglutamyl hydrolase) antibody; Gamma-glutamyl hydrolase antibody; GGH antibody; GGH_HUMAN antibody; gH antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Gamma-glutamyl hydrolase protein (219-293AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
  • 基因功能參考文獻:
    1. Either methylation of CpG1 or hypermethylation of CpG2 in GGH promoter region can significantly reduce GGH mRNA expression in pediatric patients with acute leukemia. PMID: 28278270
    2. the results of our study identify GGH as an ERG subtype specific molecular marker with modest prognostic relevance, which may have clinical relevance if analyzed in combination with other molecular markers. PMID: 28146062
    3. the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum PMID: 26676887
    4. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma PMID: 25823786
    5. Polymorphism of GGH rs3758149 C>T is associated with response to therapy in acute lymphoblastic leukemia. PMID: 24908438
    6. An interaction term, between FPGS rs7033913 heterozygotes and GGH rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to metotrexate toxicity in rheumatoid arthritis. PMID: 24447348
    7. GG genotype of GGH -354 T > G polymorphism may have high predictive value for myelosuppression in methotrexate treated rheumatoid arthritis patients. PMID: 22763757
    8. Suggest that GGH may serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast cancer. PMID: 23374458
    9. Genotyping of DHFR 829C>T and GGH -401C>T was performed using a polymerase chain reaction. PMID: 22994778
    10. The results of our study suggested the potential interest of GGH -401C>T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy. PMID: 23107767
    11. There was no significant difference in gamma-glutamyl hydrolase genotype or T allele frequency between the two groups (P> 0.05). PMID: 22678806
    12. Genetic polymorphism of gamma-glutamyl hydrolase in Chinese acute leukemia children and identification of a novel double nonsynonymous mutation. PMID: 22568793
    13. a SNP in the GGH gene remained associated with reduced CVD risk, with a stronger association in early onset CVD cases. PMID: 22649255
    14. This is one of the first studies to assess FPGS and GGH genetic variants in relation to plasma homocysteine. PMID: 22018726
    15. Genotypes in GGH gene of acute lymphoblastic leukemia patients were evaluated PMID: 21538980
    16. The -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with acute lymphoblastic leukemia. PMID: 20197200
    17. Data revealed that high FPGS gene expression, low GGH gene expression and low ABCC1 gene expression in CRC tissues were predictive factors for a high reduced folate level after LV administration. PMID: 19636555
    18. data implicate GGH as a novel biomarker for bladder cancer; suggest presence of GGH & diazepam-binding inhibitor in urine serves as a rationale for developing them as urinary markers of clinical outcomes for patients treated with neoadjuvant chemotherapy PMID: 19815704
    19. Three-dimensional structure PMID: 11953431
    20. cDNA microarray analysis led to the identification of 2 novel biomarkers that should facilitate molecular diagnosis and further study of pulmonary neuroendocrine tumors. PMID: 15492986
    21. lack of dissociation of the dimer, large monomer-monomer interface, & presence of catalytically essential Tyr-36 in the homodimer interface sequences suggest that homodimer formation is required for hGH monomer to fold into an active conformation. PMID: 16945597
    22. The genotype distribution and gene frequency of the GGH gene polymorphism was studied in a Japanese population. PMID: 17409534
    23. CpG island methylator phenotype (CIMP+) in ColoRectal Cancer (CRC) is associated with low expression of GGH, suggesting involvement of the folate pathway in the development of this phenotype. PMID: 18414409

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted, extracellular space. Lysosome. Melanosome.
  • 蛋白家族:
    Peptidase C26 family
  • 數據庫鏈接:

    HGNC: 4248

    OMIM: 601509

    KEGG: hsa:8836

    STRING: 9606.ENSP00000260118

    UniGene: Hs.78619



主站蜘蛛池模板: 湘潭县| 双峰县| 三河市| 桐城市| 兴山县| 海兴县| 周至县| 江西省| 辉南县| 毕节市| 墨江| 舒城县| 孟村| 孟村| 赞皇县| 明星| 靖江市| 祁阳县| 广州市| 大余县| 禹州市| 普安县| 夏河县| 红桥区| 兴安盟| 两当县| 克什克腾旗| 谢通门县| 望江县| 黔江区| 龙泉市| 顺平县| 汤阴县| 遂溪县| 上林县| 黎川县| 孟津县| 尉氏县| 多伦县| 霍州市| 太仆寺旗|