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Phospho-mFLNc (S2237) Antibody

  • 中文名稱：
    磷酸化-mFLNc (S2237)兔多克隆抗體
  • 貨號：
    CSB-PA837745XA01phMO
  • 規格：
    ￥440
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Filamin-C, FLN-C, ABP-280-like protein, ABP-L, Actin-binding-like protein, Filamin-2, Gamma-filamin, Flnc, Abpl, Fln2
  • 反應種屬：
    Mus musculus (Mouse)
  • 免疫原：
    Synthesized peptide derived from Mouse FLNc around the phosphorylation site of S2237.
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Affinity-purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

問答及客戶評論

■ 常見問題解答
Q:

我想要以下兩種抗體:在S2237位點磷酸化的小鼠FLNc (mFLNc)，在S2236位點磷酸化的人類FLNc (hFLNc)，這些是相同磷酸化殘基的小鼠和人類同源物。

A:
我們可以提供兔多克隆抗體生產，以產生針對S2237位點磷酸化的小鼠FLNc (mFLNc)和S2236位點磷酸化的人FLNc (hFLNc)的抗體。 我們的標準兔多克隆抗體生產方案的交付成果和保證包括: 質量保證: 1．高效液相色譜法多肽純度＞85% 2．抗體純度＞90%　SDS-PAGE證實; 3.抗體滴度　 ELISA確認:1:64,000; 交付物: 1．200ug肽- KHL/BSA偶聯物。 2．1ml免疫前血清。 3．兔多克隆抗體1mg，經肽親和層析純化。

靶點詳情

  • 功能：
    Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
  • 基因功能參考文獻：
    1. HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC PMID: 26929074
    2. The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. PMID: 26555887
    3. Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. PMID: 24963132
    4. KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. PMID: 20206623
    5. filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population PMID: 15910244
    6. These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. PMID: 16914736
    7. MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
    8. Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity PMID: 17898075

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  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Filamin family
  • 數據庫鏈接：


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