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貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.; (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.; (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
基因功能參考文獻:
The functional diversity of JAM-A resides to a large part in a C-terminal PDZ domain binding motif which directly interacts with nine different PDZ domain-containing proteins. (Review) PMID: 29238845
JAM-A was expressed in all gliomas included in this study. The JAM-A intensity increased with malignancy grade, while its prognostic value was limited. PMID: 28677106
JAM-A protein plays protective role in pathogenesis of age related diseases as Atherosclerosis, Apoplexy, thrombosis, Hypertension, Ophthalmological pathology.Short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression leading to recovery of JAM-A synthesis in cells. PMID: 28509452
Dysregulation of JAM-A via p63/GATA-3 signaling pathway occurs in squamous cell carcinomas of the head and neck. PMID: 27036044
JAM family members differentially regulate CXCR4 function and CXCL12 secretion in the bone marrow niche. PMID: 26866290
Our observations suggest that increased expression of JAM-A promotes neoplasia of lung adenocarcinoma. In addition, an anti-JAM-A antibody efficiently reduced cell proliferation and provoked apoptosis, indicating the potential feasibility of JAM-A-inhibitory cancer therapy. PMID: 28837251
a new role for CD321 in endothelial cells PMID: 29028806
We have shown that tension on JAM-A activates RhoA to control cell stiffness. Phosphorylation of JAM-A at S284 is required for activation of RhoA and increased cell stiffness in response to tension on the protein PMID: 26985018
Using patient-derived glioblastoma cancer stem cells, we confirmed that JAM-A is suppressed by miR-145 PMID: 26374689
Screening of a library of human cell surface membrane proteins showed that the Hom-1 vesivirus could utilize human junctional adhesion molecule 1 as a receptor to enter cells and initiate replication. PMID: 28196955
Our results showed that APOC3 was closely associated with the inflammatory process in ECs, and that this process was characterized by the increased expression of TNF-alpha. Inflammatory processes further disrupted the tight junctions (TJs) between HUVECs by causing increased expression of JAM-1. PMID: 27619170
High expression of junctional adhesion molecule-A and EphB2 can predict poor overall survival and high mortality rate, and EphB2 is an independent prognostic biomarker in lung adenocarcinoma patients. PMID: 28231727
JAM-A is one of the malignancy markers of HNSCC as well as beta-catenin in histopathology, and the plasma-soluble JAM-A may contribute to a serum diagnosis of HNSCC. JAM-A is a promising molecular target for diagnosis and therapy in HNSCC. PMID: 27115511
F11R mrna expression was higher in rheumatoid arthritis patients, but promoter polymorphisms did not appear to be related to disease susceptibility. PMID: 26230081
Data indicate that junctional adhesion molecule-A (JAM-A) is overexpressed in multiple myeloma (MM) cells and regulates reovirus sensitivity in MM. PMID: 26513296
JAM-A regulates the planar orientation of the mitotic spindle during epithelial morphogenesis. It triggers transient activation of Cdc42 and PI3K, generates a gradient of PtdIns(3,4,5)P3 at the cortex and regulates the formation of the actin cytoskeleton. PMID: 26306570
Data indicate that junctional adhesion molecule A (JAM-A) is a potential target of microRNA-495 {miR-495) in breast cancer cells. PMID: 25070379
JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects PMID: 25994236
JAM-A promotes proliferation and inhibits apoptosis of gastric cancer, suggesting that it has a pivotal role in gastric cancer progression. PMID: 25916097
CD14(+)CD16(+) monocytes selectively transmigrated across our BBB model as a result of their increased JAM-A and ALCAM expression. PMID: 25420915
Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis in nasopharyngeal cancer. PMID: 25416560
Low JAM-A expression correlates with poor clinical outcome and promotes cell migration and invasion in gastric cancer. PMID: 25033702
Redistribution of JAM-A in endothelial cells after stimulation with pro-atherogenic oxidized lipoproteins results in increased transmigration of mononuclear cells. PMID: 24704627
trans-dimerization of JAM-A occurs at a unique site and with different affinity compared with dimerization in cis. Trans-dimerization of JAM-A may thus act as a barrier-inducing molecular switch that is activated when cells become confluent. PMID: 24672055
JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
the clinical significance of junctional adhesion molecule A (JAM-A) in patients with non-small cell lung cancer PMID: 24265754
These studies establish F11R as a novel monocyte prognostic marker for GBM critical for defining a subpopulation of stromal cells for future potential therapeutic intervention. PMID: 24147027
JAM-A(ov) MSCs migrated into the HF sheath and remodeled HF structure effectively. PMID: 24558164
JAM-A recruits Csk to the integrin-c-Src complex, where Csk negatively regulates c-Src activation, thereby suppressing the initiation of outside-in signaling. PMID: 24300854
The entry of HIV infected and uninfected CD14(+)CD16(+) monocytes into the brain was facilitated by significantly increased surface JAM-A, ALCAM, CD99, and PECAM-1, as compared to CD14(+) cells that are CD16 negative. PMID: 23922698
Our data identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry at predilection sites of atherosclerosis. PMID: 24065611
Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation. PMID: 23389628
study concludes that JAM-A is co-expressed with HER2 and associates with aggressive breast cancer phenotypes; speculate that JAM-A may regulate HER2 proteasomal degradation and activity PMID: 22751120
Sinonasal epithelium in allergic fungal rhinosinusitis displays increased epithelial permeability and an altered expression of junctional adhesion molecule A PMID: 22927233
Low expression of junctional adhesion molecule A is associated with metastasis in pancreatic cancer PMID: 22549289
Suggest a prognostic and possibly a pathogenic role of JAM-A in arterial hypertension. PMID: 22918977
Data suggest that the Reovirus type 3 Dearing (T3D) jin mutants may be useful as oncolytic agents for use in tumors in which reovirus receptor Junction Adhesion Molecule-A (JAM-A) is absent or inaccessible. PMID: 23110175
JAM-A can interfere with tumor proliferation and suggest that JAM-A is a potential novel target in oncology. PMID: 22886345
TGF-beta1 treatment of MCF-7 cells significantly reduced JAM-A mRNA & protein via SMAD activation, & induced cell invasion. PMID: 22647687
findings provide compelling evidence of a novel role for JAM-A in driving breast cancer cell migration via activation of Rap1 GTPase and beta1-integrin PMID: 21429211
de novo synthesis of F11R in endothelial cells (EC) is required for the adhesion of platelets to inflamed ECs. PMID: 21703019
downregulation of JAM-A reduces tumor aggressive behavior by increasing cell susceptibility to apoptosis PMID: 21695058
these data identify JAM-A and fascin as novel targets of miR-145, firmly establishing a role for miR-145 in modulating breast cancer cell motility. PMID: 20818426
In addition to the previously reported role of F11R in the initiation of plaque formation, F11R plays also an important role in the subsequent growth of atherosclerotic plaques. PMID: 20627246
JAM-A expressed on CD34(+) progenitor cells regulates their adhesion to platelets or inflammatory endothelium under high shear stress in vitro and after carotid ligation in vivo or ischemia/reperfusion injury in the microcirculation of mice. PMID: 20378847
LFA-1 binding to JAM-A destabilizes the JAM-A homophilic interaction and the greater strength of the LFA-1/JAM-A complex permits it to support the tension needed to disrupt the JAM-A homophilic interaction, allowing leukocyte transendothelial migration PMID: 18849408
Two domains in the N-terminus and 1st Ig-fold of F11R were found, through which M.Ab.F11 triggers platelet aggregation. These 2 regions form an active site within the conformation of this cell adhesion molecule. PMID: 12008956
platelets adhere specifically to F11R of cytokine- (TNF-alpha, INF-gamma) stimulated vascular endothelial cells PMID: 12428104
signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis. PMID: 12750158
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亞細胞定位:
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
蛋白家族:
Immunoglobulin superfamily
組織特異性:
Expressed in endothelium, epithelium and leukocytes (at protein level).