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E2F8 Antibody

  • 中文名稱(chēng)：
    E2F8兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007349GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    E2F8
  • 別名：
    E2F 8 antibody; E2F family member 82 antibody; E2F transcription factor 8 antibody; E2F-8 antibody; E2f8 antibody; E2F8_HUMAN antibody; FLJ23311 antibody; Transcription factor E2F8 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human E2F8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
  • 基因功能參考文獻(xiàn)：
    1. MiR-1258 may function as a suppressive factor by negatively controlling E2F8 PMID: 30144184
    2. High E2F8 expression is associated with breast cancer. PMID: 26992224
    3. E2F8 can shorten cisplatin induced G2/M arrest by promoting MASTL mediated mitotic progression in ER+ breast cancer cells, conferring drug resistance. PMID: 28605876
    4. Study provides evidence that E2F8 functions as a proliferation-related oncogene in papillary thyroid cancer progression. Moreover, miR-144 appears to be a tumor suppressor through direct inhibition of E2F8. PMID: 28270228
    5. Results showed that E2F8 is up-regulated in metastatic prostate cancer and associated with poor prognosis. These results indicate that E2F8 is a crucial transcription regulator controlling cell cycle and survival in prostate cancer cells. PMID: 27683099
    6. E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development PMID: 27454291
    7. transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization PMID: 25892397
    8. E2F8 is overexpressed in Lung Cancer and is required for the growth of LC cells. E2F8 knockdown reduced the expression of UHRF1. These findings implicate E2F8 as a novel therapeutic target for LC treatment. PMID: 26089541
    9. The results identify E2F8 as a repressor and E2F1 as an activator of a transcriptional network controlling polyploidization in mammalian cells. PMID: 23064264
    10. Analyses indicated that E2F8 could bind to regulatory elements of cyclin D1, regulating its transcription and promoting accumulation of S-phase cells. Findings suggest that E2F8 contributes to the oncogenic potential of HCC PMID: 20068156
    11. The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control. PMID: 15897886
    12. E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle. PMID: 16179649
    13. E2F7 and E2F8 act upstream of E2F1, and influence the ability of cells to undergo a DNA-damage response. PMID: 18202719

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    E2F/DP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24727

    OMIM: 612047

    KEGG: hsa:79733

    STRING: 9606.ENSP00000250024

    UniGene: Hs.523526