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DRAP1 Antibody, FITC conjugated

  • 中文名稱：
    DRAP1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA05144C0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DRAP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DRAP1
  • 別名：
    DR1 associated corepressor antibody; DR1 associated protein 1 (negative cofactor 2 alpha) antibody; DR1 associated protein 1 antibody; DR1 associated protein1 antibody; Dr1-associated corepressor antibody; Dr1-associated protein 1 antibody; DRAP 1 antibody; Drap1 antibody; NC 2 alpha antibody; NC 2alpha antibody; NC2 alpha antibody; NC2-alpha antibody; NC2A_HUMAN antibody; Negative co-factor 2-alpha antibody; Negative cofactor 2 alpha antibody; Negative cofactor 2alpha antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dr1-associated corepressor protein (4-198AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
  • 基因功能參考文獻：
    1. Hypoxia actively represses transcription by inducing this protein and blocking preinitiation complex assembly. PMID: 12477712
    2. physical cooperation between BTAF1 and NC2alpha in TBP regulation PMID: 15509807
    3. The global distribution of DRAP1 on promoters was determined. PMID: 17548813
    4. provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode PMID: 17994103
    5. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    NC2 alpha/DRAP1 family
  • 組織特異性：
    Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
  • 數據庫鏈接：

    HGNC: 3019

    OMIM: 602289

    KEGG: hsa:10589

    STRING: 9606.ENSP00000307850

    UniGene: Hs.356742