国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DHPS Antibody

DHPS Antibody

  • 中文名稱：
    DHPS兔多克隆抗體
  • 貨號：
    CSB-PA006854LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006854LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DHPS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Deoxyhypusine synthase antibody; Dhps antibody; DHS antibody; DHYS_HUMAN antibody; DS antibody; MIG13 antibody; Migration inducing gene 13 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Deoxyhypusine synthase protein (1-94AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DHPS Antibody (CSB-PA006854LA01HU)，的標記方式是Non-conjugated。對于DHPS Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA006854LB01HU DHPS Antibody, HRP conjugated ELISA
    FITC CSB-PA006854LC01HU DHPS Antibody, FITC conjugated
    Biotin CSB-PA006854LD01HU DHPS Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
  • 基因功能參考文獻：
    1. the use of N1-Guanyl-1,7-diaminoheptane, a DHPS inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis. PMID: 27041563
    2. Whereas, dhps mutation study revealed that triple mutant haplotype AGEAA (S436A+A437G+K540E) associated with Sulphadoxine resistance was found among 26% of P. falciparum field isolates. PMID: 25511211
    3. eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample PMID: 22927971
    4. DHPS and WDR83 were capable of forming an RNA duplex at overlapping 3' untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation. PMID: 22491477
    5. A novel series of cell movements that orient the polarity of Lrp12/Mig13a-expressing neurons and their axons just prior to cortical plate assembly do not occur in reeler mutant mice. PMID: 20439316
    6. deoxyhypusine synthase has a role in generating spermidine or homospermidine PMID: 12788913
    7. deoxyhypusine synthase and its phosphorylation modification may have other independent cellular functions because of versatile roles of deoxyhypusine synthase PMID: 14749535
    8. crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex PMID: 15100216

    顯示更多

    收起更多

  • 蛋白家族：
    Deoxyhypusine synthase family
  • 數據庫鏈接：

    HGNC: 2869

    OMIM: 600944

    KEGG: hsa:1725

    STRING: 9606.ENSP00000210060

    UniGene: Hs.79064



主站蜘蛛池模板： 若尔盖县| 韩城市| 偃师市| 红原县| 丁青县| 永登县| 大连市| 阿荣旗| 桐城市| 闻喜县| 巴青县| 仲巴县| 陇南市| 汝州市| 沾益县| 营口市| 镇巴县| 南陵县| 自治县| 盱眙县| 白沙| 木里| 平湖市| 南开区| 淳安县| 明水县| 蓝田县| 襄樊市| 偏关县| 分宜县| 精河县| 临湘市| 彭水| 巴青县| 晋州市| 偏关县| 凤城市| 阿克苏市| 长子县| 九龙坡区| 新化县|