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  4. DGKD Antibody

DGKD Antibody

  • 中文名稱：
    DGKD兔多克隆抗體
  • 貨號：
    CSB-PA002129
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using DGK-δ Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DGKD antibody; KIAA0145Diacylglycerol kinase delta antibody; DAG kinase delta antibody; EC 2.7.1.107 antibody; 130 kDa diacylglycerol kinase antibody; Diglyceride kinase delta antibody; DGK-delta antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human DGK-δ.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis.
  • 基因功能參考文獻：
    1. purification and characterization of DGKepsilon's enzymatic and conformational properties PMID: 28199087
    2. Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2. PMID: 23184957
    3. This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population. PMID: 22406787
    4. Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane. PMID: 20857926
    5. Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8. PMID: 20064931
    6. Alternative splicing of the gene generates two isoforms differing in their expression patterns and in regulatory functions PMID: 12200442
    7. Phosphorylation is involved in the control of subcellular localization of DGKdelta1. PMID: 15228384
    8. Disruption of diacylglycerol kinase delta (DGKD) is associated with seizures in humans and mice. PMID: 17357084
    9. Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients. PMID: 18267070
    10. Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. PMID: 18334213

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  • 亞細胞定位：
    Membrane, clathrin-coated pit. Cytoplasm.; [Isoform 1]: Cell membrane; Peripheral membrane protein. Cytoplasm.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 組織特異性：
    [Isoform 2]: Widely expressed.; [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen.
  • 數據庫鏈接：

    HGNC: 2851

    OMIM: 601826

    KEGG: hsa:8527

    STRING: 9606.ENSP00000264057

    UniGene: Hs.471675



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