CYP39A1 Antibody

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CYP39A1 Polyclonal antibody
Uniprot No.：

Q9NYL5
基因名：

CYP39A1
別名：

24 hydroxycholesterol 7 alpha hydroxylase antibody; 24-hydroxycholesterol 7-alpha-hydroxylase antibody; CP39A_HUMAN antibody; Cyp39a1 antibody; cytochrome P450 family 39; subfamily A polypeptide 1 antibody; Cytochrome P450 39A1 antibody; cytochrome P450 subfamily XXXIX (oxysterol 7 alpha hydroxylase) polypeptide 1 antibody; Cytochrome P450; family 39; subfamily a; polypeptide 1 antibody; hCYP39A1 antibody; Oxysterol 7 alpha hydroxylase antibody; Oxysterol 7-alpha-hydroxylase antibody; oxysterol 7alpha hydroxylase antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human 24-hydroxycholesterol 7-alpha-hydroxylase protein (235-392AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，CYP39A1 Antibody (CSB-PA882143LA01HU)，的標(biāo)記方式是Non-conjugated。對于CYP39A1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA882143LB01HU	CYP39A1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA882143LC01HU	CYP39A1 Antibody, FITC conjugated
Biotin	CSB-PA882143LD01HU	CYP39A1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
基因功能參考文獻(xiàn)：
1. The CYP39A1 polymorphism rs7761731 may help to identify patients at high risk for treatment related toxicity. PMID: 26475344
2. GSTA1 and CYP39A1 were found to be associated with busulfan clearance. When combined, the two haplotypes explained 17% of the variability in busulfan clearance. PMID: 24192117
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
蛋白家族：

Cytochrome P450 family
組織特異性：

Liver specific.
數(shù)據(jù)庫鏈接：

HGNC: 17449

OMIM: 605994

KEGG: hsa:51302

STRING: 9606.ENSP00000275016

UniGene: Hs.387367

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