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  4. COMMD5 Antibody

COMMD5 Antibody

  • 中文名稱：
    COMMD5兔多克隆抗體
  • 貨號：
    CSB-PA005773GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    COMMD5
  • 別名：
    COMMD5 antibody; HT002COMM domain-containing protein 5 antibody; Hypertension-related calcium-regulated gene protein antibody; HCaRG antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human COMMD5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
  • 基因功能參考文獻：
    1. the hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is involved in renal repair. PMID: 24515317
    2. HCaRG accelerates repair of renal proximal tubules by modulating cell proliferation of resident tubular epithelial cells and by facilitating redifferentiation. PMID: 21921141
    3. The gene for human HCaRG is located on chromosome 8q24.3. PMID: 11871861
    4. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer. PMID: 18949406
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
  • 數據庫鏈接：

    HGNC: 17902

    OMIM: 608216

    KEGG: hsa:28991

    STRING: 9606.ENSP00000304544

    UniGene: Hs.493218



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