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CLPP Antibody

  • 中文名稱：
    CLPP兔多克隆抗體
  • 貨號：
    CSB-PA618094LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA618094LA01HU diluted at 1:500 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA618094LA01HU diluted at 1:500 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CLPP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLPP
  • 別名：
    ATP dependent protease ClpAP (E coli) proteolytic subunit antibody; ATP dependent protease ClpAP proteolytic subunit antibody; ATP dependent protease ClpAP proteolytic subunit human antibody; ATP dependent proteolytic subunit homolog (E coli) antibody; ATP dependent proteolytic subunit homolog antibody; Caseinolytic peptidase ATP dependent proteolytic subunit homolog antibody; Caseinolytic protease ATP dependent proteolytic subunit E coli antibody; clpP antibody; ClpP caseinolytic peptidase ATP dependent proteolytic subunit antibody; ClpP caseinolytic peptidase ATP dependent proteolytic subunit homolog antibody; CLPP_HUMAN antibody; Endopeptidase Clp antibody; mitochondrial antibody; Putative ATP dependent Clp protease proteolytic subunit mitochondrial antibody; Putative ATP dependent Clp protease proteolytic subunit antibody; Putative ATP-dependent Clp protease proteolytic subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent Clp protease proteolytic subunit, mitochondrial protein (223-277AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CLPP Antibody (CSB-PA618094LA01HU)，的標記方式是Non-conjugated。對于CLPP Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA618094LB01HU CLPP Antibody, HRP conjugated ELISA
    FITC CSB-PA618094LC01HU CLPP Antibody, FITC conjugated
    Biotin CSB-PA618094LD01HU CLPP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
  • 基因功能參考文獻：
    1. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. PMID: 28449241
    2. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. PMID: 27154400
    3. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    4. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence. PMID: 27389535
    5. Data indicate endopeptidase Clp (ClpP) mutation identified in two patients with Perrault syndrome type 3 in a Turkish family. PMID: 27087618
    6. ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions . PMID: 26606371
    7. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability. PMID: 25083874
    8. Deletion of PaClpP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina and This phenotype can be reverted by expression of human ClpP. PMID: 23360988
    9. Perrault syndrome is caused by recessive mutations in CLPP. PMID: 23541340
    10. the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well PMID: 15522782
    11. hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles PMID: 16115876
    12. We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts PMID: 18378094

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  • 相關疾病：
    Perrault syndrome 3 (PRLTS3)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase S14 family
  • 組織特異性：
    Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
  • 數據庫鏈接：

    HGNC: 2084

    OMIM: 601119

    KEGG: hsa:8192

    STRING: 9606.ENSP00000245816

    UniGene: Hs.515092



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