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CEP19 Antibody

  • 中文名稱：
    CEP19兔多克隆抗體
  • 貨號：
    CSB-PA850384LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850384LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CEP19 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CEP19
  • 別名：
    CEP19 antibody; C3orf34 antibody; HSD5 antibody; Centrosomal protein of 19 kDa antibody; Cep19 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 19 kDa protein (1-163AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CEP19 Antibody (CSB-PA850384LA01HU)，的標記方式是Non-conjugated。對于CEP19 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA850384LB01HU CEP19 Antibody, HRP conjugated ELISA
    FITC CSB-PA850384LC01HU CEP19 Antibody, FITC conjugated
    Biotin CSB-PA850384LD01HU CEP19 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes.
  • 基因功能參考文獻：
    1. RABL2 binds to CEP19 and the IFT74-IFT81 heterodimer in a mutually exclusive manner. PMID: 28428259
    2. CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange. PMID: 28625565
    3. loss of the ciliary protein CEP19 in humans and mice causes morbid obesity. PMID: 24268657
  • 相關疾病：
    Morbid obesity and spermatogenic failure (MOSPGF)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    CEP19 family
  • 數據庫鏈接：

    HGNC: 28209

    OMIM: 615586

    KEGG: hsa:84984

    STRING: 9606.ENSP00000387209

    UniGene: Hs.282800