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BZLF2 Antibody, Biotin conjugated

Rare Species
  • 中文名稱：
    BZLF2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA365876LD01EFA
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Epstein-Barr virus BZLF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BZLF2
  • 別名：
    BZLF2Glycoprotein 42 antibody; gp42) [Cleaved into: Soluble gp42] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Epstein-Barr virus
  • 免疫原：
    Recombinant Epstein-Barr virus Glycoprotein 42 protein (34-223AA)
  • 免疫原種屬：
    Epstein-Barr virus
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells. Additionally, hampers T-cell recognition via HLA class II molecules through steric hindrance of T-cell receptor-class II-peptide interaction.; Soluble gp42 inhibits HLA class II-restricted antigen presentation to T-cells through binding to immature and mature HLA class II complexes.
  • 基因功能參考文獻：
    1. gp42 mutants bound to gH/gL and HLA class II, but not wild-type gp42 or cleavage mutant of gp42; using purified gp42, gH/gL, and HLA, found these proteins associate 1:1:1 suggesting gp42 dimerization or multimerization does not occur or is transient PMID: 21550622
    2. reveal distinct functional requirements for gH/gL and gp42 complexes in Epstein-Barr virus-mediated membrane fusion PMID: 16973550
    3. This screening demonstrates that LF2 specifically interacts with the central inhibitory association domain of IRF7, and this interaction leads to inhibition of the dimerization of IRF7, which suppresses IFN-alpha production and IFN-mediated immunity. PMID: 18987133
    4. Enhanced secretion of gp42 promoted fusion with B lymphocytes, and mutation of the site of gp42 cleavage inhibited membrane fusion activity. PMID: 19369343
  • 亞細胞定位：
    Virion membrane. Host membrane; Single-pass membrane protein.
  • 蛋白家族：
    Epstein barr virus gp42 family
  • 數據庫鏈接：

    KEGG: vg:3783745