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BOC Antibody

  • 中文名稱：
    BOC兔多克隆抗體
  • 貨號：
    CSB-PA866299ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA866299ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866299ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BOC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BOC antibody; UNQ604/PRO1190Brother of CDO antibody; Protein BOC antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Brother of CDO protein (1-125AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
  • 基因功能參考文獻(xiàn)：
    1. we report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays. PMID: 28677295
    2. BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. PMID: 27871935
    3. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype PMID: 28915250
    4. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
    5. Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm. PMID: 20053908
    6. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
    7. Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. PMID: 16647304
    8. BOC, along with CDO, defines a new subfamily of the immunoglobulin superfamily that is conserved from Drosophila to man. BOC and CDO form a putative receptor complex that stimulates differentiation of myoblasts. PMID: 11782431

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell contact.
  • 組織特異性：
    Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17173

    OMIM: 608708

    KEGG: hsa:91653

    STRING: 9606.ENSP00000347546

    UniGene: Hs.591318



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