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BEST2 Antibody

  • 中文名稱：
    BEST2兔多克隆抗體
  • 貨號：
    CSB-PA080178
  • 規格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using BEST2 Polyclonal Antibody.
    • Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue using BEST2 Polyclonal Antibody.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    BEST2
  • 別名：
    BEST2; VMD2L1; Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1000
    IHC 1:200-500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
  • 基因功能參考文獻：
    1. BEST2 and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells PMID: 24223998
    2. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    3. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon PMID: 20407206
    4. These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans. PMID: 20157619
    5. identified three novel VMD2-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains [VMD2L1, VMD2L2, VMD2L3] PMID: 12032738
    6. Results provide evidence that the bestrophins are expressed in pancreatic duct cells and, more specifically, that hBest1 plays a role in the calcium activated chloride channels found in these cells. PMID: 19237432
    7. we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW] PMID: 19398034

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Bestrophin family
  • 組織特異性：
    Mainly confined to the retinal pigment epithelium and colon.
  • 數據庫鏈接：

    HGNC: 17107

    OMIM: 607335

    KEGG: hsa:54831

    STRING: 9606.ENSP00000042931

    UniGene: Hs.435611