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ATP6V1E1 Antibody

  • 中文名稱：
    ATP6V1E1兔多克隆抗體
  • 貨號：
    CSB-PA02295A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ATP6V1E1 antibody at 2µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 27, 24, 23 kDa
      Observed band size: 36 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA02295A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ATP6V1E1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ATP6V1E1 antibody; ATP6E antibody; ATP6E2 antibody; V-type proton ATPase subunit E 1 antibody; V-ATPase subunit E 1 antibody; V-ATPase 31 kDa subunit antibody; p31 antibody; Vacuolar proton pump subunit E 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human V-type proton ATPase subunit E 1 protein (2-224AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ATP6V1E1 Antibody (CSB-PA02295A0Rb)，的標記方式是Non-conjugated。對于ATP6V1E1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA02295B0Rb ATP6V1E1 Antibody, HRP conjugated ELISA
    FITC CSB-PA02295C0Rb ATP6V1E1 Antibody, FITC conjugated
    Biotin CSB-PA02295D0Rb ATP6V1E1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
  • 基因功能參考文獻：
    1. expression of the V-ATPase V1E1 has prognostic significance in esophageal squamous cell carcinoma, and is closely linked to migration, invasion, and aerobic glycolysis in esophageal cancer cells PMID: 27384996
    2. Low-grade PanIN lesions with typical columnar morphology displayed diffuse labeling of the V1E subunit. In advanced lesions it was found along the basolateral membranes. PMID: 25072283
    3. The genes CECR2, SLC25A18 and ATP6V1E1, mapping within the critical region for cat eye syndrome (CES), may be responsible for anorectal, renal and preauricular anomalies in patients with CES. PMID: 22395867
    4. Data demonstrate the physiological significance of the interaction between the E and H subunits of V-ATPase and extend previous studies on the arrangement of subunits on the peripheral stalk of V-ATPase. PMID: 12163484
    5. HuR shows increased binding to some V-ATPase mRNAs during ATP depletion; siRNA-mediated knockdown of HuR results in diminished V-ATPase expression PMID: 16155006
    6. Rat vacuolar H(+)ATPase associates with NHE-RF (Na(+)/H(+) exchanger regulatory factor); the E subunit was co-immunoprecipitated from rat kidney cytosol with NHE-RF antibodies. PMID: 10748165
    7. The mouse V-ATPase E may participate in the regulation of the mSos1-dependent Rac1 signaling pathway involved in growth factor receptor-mediated cell growth control. PMID: 11560919

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  • 相關疾病：
    Cutis laxa, autosomal recessive, 2C (ARCL2C)
  • 亞細胞定位：
    Apical cell membrane.
  • 蛋白家族：
    V-ATPase E subunit family
  • 組織特異性：
    Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). Ubiquitous. High expression in the skin.
  • 數據庫鏈接：

    HGNC: 857

    OMIM: 108746

    KEGG: hsa:529

    STRING: 9606.ENSP00000253413

    UniGene: Hs.517338



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