国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

ARAP3 Antibody, HRP conjugated

  • 中文名稱:
    ARAP3兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA819904LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ARAP3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ARAP3 antibody; CENTD3 antibody; Arf-GAP with Rho-GAP domain antibody; ANK repeat and PH domain-containing protein 3 antibody; Centaurin-delta-3 antibody; Cnt-d3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 protein (163-320AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
  • 基因功能參考文獻:
    1. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. PMID: 27311713
    2. structural and binding affinity between odin and arap3 PMID: 23239578
    3. Phosphoinositide 3-OH kinase (PI3K) is input into the regulation of beta2 integrin activity, and processes dependent on its responses, by signaling through its effector ARAP3. PMID: 23180820
    4. The structural basis for the interaction between Arap3 and Vav2, hydrophobic pockets and binding specificity. PMID: 22750419
    5. ARAP3 is a unique Src substrate that suppresses peritoneal dissemination of scirrhous gastric carcinoma cells. PMID: 21076469
    6. None of the individual PH domains can bind to PtdIns(3,4,5)P3; rather, a fragment comprising two PH domains and an N-terminal linker is minimally required for binding. PMID: 19786092
    7. The catalytic domain of ARF-GAP alone is sufficient to initiate uncoating of liposome-derived COPI-coated vesicles. ARF-GAP activity is not required for COPI coat assembly & does not seem to be an essential coat component of COPI vesicles. PMID: 12832619
    8. ARAP3 has a role in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading PMID: 15546919
    9. ARAP3 deficiency produced by antisense expression of an ARAP3 EST impaired entry of anthrax PA and its bound toxigenic moieties into both human and mouse cells, resulting in reduced toxin sensitivity PMID: 15569923
    10. In a yeast two-hybrid screen for new interaction partners of Arap3, the PI 5'-phosphatase SHIP2 was identified as an interaction partner of Arap3. PMID: 17314030

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle.
  • 數據庫鏈接:

    HGNC: 24097

    OMIM: 606647

    KEGG: hsa:64411

    STRING: 9606.ENSP00000239440

    UniGene: Hs.726187



主站蜘蛛池模板: 恩施市| 华池县| 南投市| 读书| 隆林| 翁源县| 秦皇岛市| 嘉鱼县| 深州市| 兰溪市| 泾川县| 长海县| 启东市| 忻城县| 富川| 岢岚县| 永靖县| 奎屯市| 静乐县| 城步| 湘潭市| 临城县| 咸丰县| 福鼎市| 双辽市| 雷山县| 镶黄旗| 华安县| 新郑市| 灵川县| 且末县| 太和县| 郎溪县| 吐鲁番市| 淮北市| 兰溪市| 镶黄旗| 桦南县| 阜康市| 巴彦淖尔市| 旬阳县|