国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCA2 Antibody

ABCA2 Antibody

  • 中文名稱：
    ABCA2兔多克隆抗體
  • 貨號：
    CSB-PA887172LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA887172LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA887172LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ABCA2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ABC2 antibody; Abca2 antibody; ABCA2_HUMAN antibody; ATP binding cassette 2 antibody; ATP binding cassette sub family A member 2 antibody; ATP binding cassette transporter 2 antibody; ATP binding cassette; sub family A (ABC1); member 2 antibody; ATP binding cassette; sub family A; member 2 antibody; ATP binding cassette; sub family B (MDR/TAP); member 2 antibody; ATP-binding cassette 2 antibody; ATP-binding cassette sub-family A member 2 antibody; ATP-binding cassette transporter 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-binding cassette sub-family A member 2 protein (1223-1429AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ABCA2 Antibody (CSB-PA887172LA01HU)，的標記方式是Non-conjugated。對于ABCA2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA887172LB01HU ABCA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA887172LC01HU ABCA2 Antibody, FITC conjugated
    Biotin CSB-PA887172LD01HU ABCA2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
  • 基因功能參考文獻：
    1. The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
    2. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
    3. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
    4. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
    5. A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
    6. we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
    7. roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
    8. Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
    9. It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
    10. Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
    11. Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
    12. the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
    13. Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
    14. No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

    顯示更多

    收起更多

  • 亞細胞定位：
    Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 組織特異性：
    [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 32

    OMIM: 600047

    KEGG: hsa:20

    STRING: 9606.ENSP00000344155

    UniGene: Hs.421202



主站蜘蛛池模板： 逊克县| 泽州县| 石首市| 寻甸| 敦煌市| 莒南县| 武川县| 黑水县| 玉田县| 镇江市| 商河县| 淮阳县| 芒康县| 客服| 武乡县| 岐山县| 勐海县| 鲁山县| 通化县| 页游| 广德县| 新绛县| 惠水县| 阳信县| 石泉县| 宁海县| 开阳县| 咸阳市| 盘锦市| 项城市| 沭阳县| 微山县| 赤壁市| 昭平县| 定日县| 深圳市| 肇源县| 台东县| 长沙市| 陆川县| 静海县|