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TTLL12 Monoclonal Antibody

  • 中文名稱：
    TTLL12 Monoclonal Antibody
  • 貨號：
    CSB-MA595714
  • 規格：
    ￥1320
  • 圖片：
    • Western blotting analysis using TTLL12 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with TTLL12 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) TTLL12 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    TTLL12
  • 別名：
    TTLL12; Tubulin Tyrosine Ligase Like 12; KIAA0153; Inactive Tubulin--Tyrosine Ligase-Like Protein 12; Tubulin--Tyrosine Ligase-Like Protein 12; Tubulin Tyrosine Ligase-Like Family, Member 12; Tubulin Tyrosine Ligase-Like Family Member 12; DJ526I14.2
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TTLL12 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    24H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
  • 基因功能參考文獻：
    1. TTLL12 as a negative regulator of RNA-virus-induced type I IFN expression by inhibiting the interaction of VISA with other proteins. PMID: 28011935
    2. A new TTLL12 isoform may be of importance for proper maintenance of lung cancer cells. PMID: 27748896
    3. results suggest that hTTLL12 has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability PMID: 23251473
    4. Results raise the possibility that TTLL12 could contribute to tumorigenesis through effects on the cytoskeleton, tubulin modification and chromosome number stability. PMID: 20162578
  • 亞細胞定位：
    Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
  • 組織特異性：
    Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.
  • 數據庫鏈接：

    HGNC: 28974

    KEGG: hsa:23170

    STRING: 9606.ENSP00000216129

    UniGene: Hs.517670