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  4. TSNAX Monoclonal Antibody

TSNAX Monoclonal Antibody

  • 中文名稱：
    TSNAX Monoclonal Antibody
  • 貨號：
    CSB-MA262913
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of TSNAX expression in HeLa cells using TSNAX antibody. Green, isotype control; red, TSNAX.
    • Validation of TSNAX knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with TSNAX antibody and analyzed using BD flow cytometer.
    • Immunocytochemical staining of HeLa cells using TSNAX antibody , Top panel: wild-type (WT); Bottom panal: TSNAX shRNA knockdown (KD). Nuclei were stained blue with DAPI; TSNAX was stained magenta with Alexa Fluor? 647. Scale bar, 20 μm.
    • Western blotting analysis using TSNAX antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with TSNAX antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
    • Western blotting analysis using TSNAX antibody. TSNAX expression in wild-type (WT) and TSNAX shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with TSNAX antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) TSNAX Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    TSNAX
  • 別名：
    TSNAX; Translin Associated Factor X; TRAX; C3PO; Translin-Associated Protein X; Translin-Associated Factor X; Translin-Like Protein
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human TSNAX protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    12D2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:400-1:2000
    FC 1:100-1:1000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
  • 基因功能參考文獻：
    1. TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation. PMID: 25043320
    2. High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma. PMID: 25239642
    3. LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. PMID: 24928020
    4. Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. PMID: 22889834
    5. Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder PMID: 22673686
    6. TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. PMID: 22427937
    7. The results of this suggested an association between the TSNAX-DISC1 region and both forms of affective disorders. PMID: 19255581
    8. Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population. PMID: 19760522
    9. TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation PMID: 14711818
    10. One region in TRAX showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men. PMID: 15838535

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  • 亞細胞定位：
    Cytoplasm, perinuclear region. Golgi apparatus. Nucleus.
  • 蛋白家族：
    Translin family
  • 數據庫鏈接：

    HGNC: 12380

    OMIM: 602964

    KEGG: hsa:7257

    STRING: 9606.ENSP00000355599

    UniGene: Hs.13318