国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. TRIP13 Monoclonal Antibody

TRIP13 Monoclonal Antibody

  • 中文名稱：
    TRIP13 Monoclonal Antibody
  • 貨號：
    CSB-MA082044
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Thyroid hormone receptor interactor 13 expression in HAP-1 cells using Thyroid hormone receptor interactor 13 antibody. Green, isotype control; red, Thyroid hormone receptor interactor 13.
    • Western blotting analysis using thyroid hormone receptor interactor 13 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with thyroid hormone receptor interactor 13 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) TRIP13 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    TRIP13
  • 別名：
    TRIP13; Thyroid Hormone Receptor Interactor 13; 16E1BP; Human Papillomavirus Type 16 E1 Protein-Binding Protein; Thyroid Receptor-Interacting Protein 13; Pachytene Checkpoint Protein 2 Homolog; TR-Interacting Protein 13; 16E1-BP; TRIP-13; Thyroid Receptor Interacting Protein 13; HPV16 E1 Protein Binding Protein; HPV16 E1 Protein-Binding Protein; SH3TC1/TRIP13 Fusion; OZEMA9; OOMD9; MVA3; PCH2
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TRIP13 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6H9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2500-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation.
  • 基因功能參考文獻：
    1. heightened TRIP13 expression appears to promote lung adenocarcinoma tumor progression. PMID: 29567476
    2. TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region. PMID: 29208896
    3. Microarray analyses indicated that the biological function of TRIP13 in CLL is majorly cell apoptosis and cell proliferation associated. TRIP13 siRNA expressing cells exhibited a slower cell proliferation rate and underwent apoptosis compared with control cells. PMID: 28424416
    4. TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM. PMID: 28157697
    5. These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2. PMID: 28564602
    6. 6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC impairment. PMID: 28553959
    7. Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP. PMID: 28659378
    8. These results establish a paradigm of the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation. PMID: 26832417
    9. the oligomeric form of TRIP13 binds both p31(comet) and MCC PMID: 26324890
    10. TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer. PMID: 25078033
    11. suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development PMID: 25012665
    12. propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation PMID: 25092294

    顯示更多

    收起更多

  • 相關疾病：
    Mosaic variegated aneuploidy syndrome 3 (MVA3)
  • 蛋白家族：
    AAA ATPase family, PCH2 subfamily
  • 數據庫鏈接：

    HGNC: 12307

    OMIM: 604507

    KEGG: hsa:9319

    STRING: 9606.ENSP00000166345

    UniGene: Hs.436187