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  4. TRIM7 Monoclonal Antibody

TRIM7 Monoclonal Antibody

  • 中文名稱：
    TRIM7 Monoclonal Antibody
  • 貨號：
    CSB-MA908113
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of TRIM7 expression in HeLa cells using TRIM7 antibody. Green, isotype control; red, TRIM7.
    • Western blotting analysis using TRIM7 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with TRIM7 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
    • Western blotting analysis using TRIM7 antibody. TRIM7 expression in wild type (WT) and TRIM7 knockout (KO) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with TRIM7 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) TRIM7 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    TRIM7
  • 別名：
    TRIM7; Tripartite Motif Containing 7; GNIP; Glycogenin-Interacting Protein; E3 Ubiquitin-Protein Ligase TRIM7; Tripartite Motif Protein TRIM7; RING Finger Protein 90; Tripartite Motif-Containing Protein 7; Tripartite Motif-Containing 7; EC 2.3.2.27
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TRIM7 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19B5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:400-1:2000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation. Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon. Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation.; (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.
  • 基因功能參考文獻：
    1. TRIM28 is a specific SUMO E3 ligase of interferon regulatory factor (IRF)7 and negatively regulates its activity and interferon (IFN)-based antiviral responses, in support of the expanding roles of TRIM proteins which regulate innate immunity. PMID: 21940674
    2. GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis PMID: 11916970
  • 亞細胞定位：
    Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart.
  • 數據庫鏈接：

    HGNC: 16278

    OMIM: 609315

    KEGG: hsa:81786

    STRING: 9606.ENSP00000274773

    UniGene: Hs.487412