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  4. TIMM23 Monoclonal Antibody

TIMM23 Monoclonal Antibody

  • 中文名稱：
    TIMM23 Monoclonal Antibody
  • 貨號：
    CSB-MA903029
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of TIMM23 expression in HeLa cells using TIMM23 antibody. Green, isotype control; red, TIMM23.
    • Western blotting analysis using TIMM23 antibody. Total cell lysates (20 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with TIMM23 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) TIMM23 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    TIMM23
  • 別名：
    TIMM23; Translocase Of Inner Mitochondrial Membrane 23; TIM23; Mitochondrial Import Inner Membrane Translocase Subunit Tim23; Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast); Translocase Of Inner Mitochondrial Membrane 23 Homolog; Translocase Of The Inner Mitochondrial Membrane
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TIMM23 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13B11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
  • 基因功能參考文獻：
    1. Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression. PMID: 29413900
    2. The interaction of presequence peptides with Tim23 intermembrane space domain is weakened in presence of Ca2+ ion, which implicates that Ca2+ ion may play an important role in the protein import by TIM23 complex. PMID: 27178215
    3. Modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency. PMID: 25519239
    4. Three distinct Tim23 complexes, namely, B1, B2, and A, are involved in the maintenance of normal mitochondrial function. PMID: 24636990
    5. GST pull-down experiments and tryptophan fluorescence indicated that there is no interaction between Tim23IMS and Tim50IMS PMID: 23811401
    6. MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. PMID: 23263864
    7. Study establishes an unexpected molecular link between the TIM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein synthesis in response to their assembly state. PMID: 23260140
    8. The non-bound hydrophilic domain of the human Tim23 is in a molten globule configuration with marginal stability, existing as a dimer. PMID: 22306744

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  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tim17/Tim22/Tim23 family
  • 數據庫鏈接：

    HGNC: 17312

    OMIM: 605034

    KEGG: hsa:100287932

    STRING: 9606.ENSP00000260867

    UniGene: Hs.524308