SPTAN1 Monoclonal Antibody
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中文名稱:SPTAN1 Monoclonal Antibody
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貨號:CSB-MA824987
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規格:¥1320
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圖片:
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Flow cytometric analysis of SPTAN1 expression in C2C12 cells using SPTAN1 antibody. Green, isotype control; red, SPTAN1.
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Immunocytochemical staining of C2C12 cells with SPTAN1 antibody. Nuclei were stained blue with DAPI; SPTAN1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm. Permeabilization: Triton.
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Western blotting analysis using SPTAN1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SPTAN1 antibody and HRP-conjugated goat mouse secondary antibody respectively.
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其他:
產品詳情
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產品名稱:Mouse anti-Homo sapiens (Human) SPTAN1 Monoclonal antibody
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Uniprot No.:
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基因名:
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別名:SPTAN1; Spectrin Alpha, Non-Erythrocytic 1; Spectrin Alpha Chain, Non-Erythrocytic 1; Spectrin, Non-Erythroid Alpha Subunit; Fodrin Alpha Chain; Alpha-II Spectrin; Alpha-Fodrin; SPTA2; Epididymis Secretory Sperm Binding Protein; Spectrin, Non-Erythroid Alpha Chain; HMND11; DEVEP; EIEE5; HMN11; SPG91; DEE5
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宿主:Mouse
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反應種屬:Human, Mouse, Rat
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免疫原:Recombinant Human SPTAN1 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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抗體亞型:Mouse IgG1
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純化方式:Affinity-chromatography
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克隆號:16D5
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產品提供形式:Liquid
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應用范圍:ELISA, WB, FC, ICC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2500 FC 1:200-1:2000 ICC 1:100-1:1000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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功能:Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
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基因功能參考文獻:
- Spectrin may be engaged in regulation of distinct events necessary for the establishment and maturity of the immunological synapse. PMID: 29244882
- SPTAN1-related disorders comprise a wide spectrum of neurodevelopmental phenotypes ranging from mild to severe and progressive. Spectrin aggregate formation in fibroblasts with mutations in the alpha/beta heterodimerization domain seems to be associated with a severe neurodegenerative course. PMID: 29050398
- Alpha-spectrin is critical for recruitment of non-ubiquitinated FANCD2 to sites of damage, which has an important role in the repair response and interstrand cross-link repair. PMID: 26297932
- Studies demonstrate that alpha-IISp plays a critical role in maintaining chromosome stability in cells after DNA interstrand cross-links damage by repairing damage that occurs in both genomic and telomeric DNA. PMID: 25757157
- These results suggest that ubiquitin C-terminal hydrolase and alphaII-spectrin breakdown product 145 kDa may be useful in assessing outcome after pediatric traumatic brain injury. PMID: 22022780
- Variations in both alpha-spectrin (SPTA1) and beta-spectrin ( SPTB ) were found in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis. PMID: 24193021
- aggressiveness of MLH1-positive colorectal cancers might be related to SPTAN1. PMID: 24456667
- hypomyelination of the cerebral white matter was revealed at the age of 1 year, and a de novo heterozygous mutation in the SPTAN1 gene was confirmed PMID: 22656320
- loss of SPTAN1 switches TGF-beta signaling from tumor suppression to tumor promotion by engaging Notch signaling and activating SOX9 in esophageal adenocarcinoma. PMID: 23536563
- organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin PMID: 22163289
- In-frame mutations in the C-terminus of SPTAN1 cause a core set of manifestations that include severe intellectual disability, generalized epilepsy, and pontocerebellar atrophy. PMID: 22258530
- Analysis of alphaII-spectrin breakdown products in cerebrospinal fluid predicts mortality and injury severity in adults following traumatic brain injury. PMID: 20408766
- findings suggest that pathological aggregation of alpha/beta spectrin heterodimers and abnormal axon initial segment(AIS) integrity resulting from SPTAN1 mutations were involved in pathogenesis of infantile epilepsy PMID: 20493457
- Fanconi anemia proteins may play an important role in maintaining the stability of alphaIISp in the cell by regulating its cleavage by mu-calpain. PMID: 20518497
- This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
- SigA binds to epithelial HEp-2 cells as well as being able to induce fodrin degradation in vitro and in situ, further extending its documented role in the pathogenesis of Shigella infections. PMID: 20011051
- Review. 120 kDa alpha-fodrin is an important autoantigen in both animal models and Sjogren syndrome patients. Increased caspase cascade activity may be involved in the progression of alpha-fodrin proteolysis and tissue destruction. PMID: 12630566
- High affinity and slow overall kinetics of association/dissociation of alpha II-spectrin may suit it well to a role in strengthening cell junctions and providing stable anchorage for transmembrane proteins at points specified by cell-adhesion molecules. PMID: 12820899
- Fanconi anemia cell lines deficient in alphaII spectrin express normal levels of alphaII spectrin mRNA. PMID: 12893251
- These observations indicate that calpain is activated and reacts with alpha-fodrin as a substrate at the sarcolemma, and plays a key role in modulating sarcolemmal proteins to adapt to the specific conditions in each myopathy. PMID: 15948206
- The in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome was analyzed. PMID: 16192640
- These studies indicate that alphaSpIISigma( *) may play a role in a number of diverse and important processes in the nucleus and that a deficiency in this protein, as occurs in Fanconi's anemia, could affect a number of critical cellular pathways. PMID: 16889989
- provide novel insights into spectrin functions by demonstrating the involvement of alphaII-spectrin in cell cycle regulation and actin organization PMID: 18978357
- The SH3 domain of SPTAN1 is a target for the Fanconi anemia protein, FANCG. PMID: 19102630
- depletion of alphaIISp in normal cells leads to a number of defects observed in Fanconi anemia cells, such as chromosome instability and a deficiency in cross-link repair. PMID: 19217883
- fodrin degradation occurs during galectin-1 T cell death and CD45 is essential for fodrin degradation to occur PMID: 19454697
- This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380
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相關疾?。?/div>Epileptic encephalopathy, early infantile, 5 (EIEE5)亞細胞定位:Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.蛋白家族:Spectrin family數據庫鏈接:
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