国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. SNX9 Monoclonal Antibody

SNX9 Monoclonal Antibody

  • 中文名稱：
    SNX9 Monoclonal Antibody
  • 貨號：
    CSB-MA242632
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of SNX9 expression in HeLa cells using SNX9 antibody. Green, isotype control; red, SNX9.
    • Immunocytochemical staining of Hela cells with SNX9 antibody. Nuclei were stained blue with DAPI; SNX9 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using SNX9 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SNX9 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) SNX9 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    SNX9
  • 別名：
    SNX9; Sorting Nexin 9; SH3PXD3A; SH3PX1; SDP1; SH3 And PX Domain-Containing Protein 3A; SH3 And PX Domain-Containing Protein 1; Sorting Nexin-9; Wiskott-Aldrich Syndrome Protein (WASP) Interactor Protein; Protein SDP1; WISP
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SNX9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    22A2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
  • 基因功能參考文獻：
    1. In conclusion, the authors identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease. PMID: 28266622
    2. The diversified changes associated with SNX9 expression in cancer highlight its importance as a central regulator of cancer cell behavior. PMID: 27278018
    3. reduced levels of SNX9 were observed in blood samples from colorectal cancer patients, emphasizing the feasibility of its use as a diagnostic and prognostic biomarker sensing the host's immune status and inflammatory stage. PMID: 26608909
    4. this study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrin-mediated endocytosis. PMID: 25256216
    5. SNX9 and CHC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association. PMID: 23861900
    6. The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. PMID: 22718350
    7. study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions. PMID: 20964629
    8. Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9. PMID: 20088948
    9. The interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9. PMID: 20491914
    10. SNX9 binding to aldolase is structurally precluded by the binding of substrate to the active site. PMID: 20129922
    11. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation PMID: 11799118
    12. SNX9 may function to assist AP-2 in its role at the plasma membrane. PMID: 11879186
    13. SNX9 may be recruited together with dynamin-2 and become co-assembled with AP-2 and clathrin at the plasma membrane PMID: 12952949
    14. SNX9-dependent recruitment of Dyn2 to the membrane is regulated by an interaction between SNX9 and aldolase PMID: 15299020
    15. SNX9 is required for efficient clathrin-mediated endocytosis and suggest that it functions to regulate dynamin activity PMID: 15703209
    16. Dimerization, which is mediated by the BAR domain, is essential for the intracellular function of SH3PX1. PMID: 16316319
    17. identified sorting nexin 9 (SNX9) as a host cell enteropathogenic E. coli EspF binding partner protein, which binds EspF via its amino-terminal SH3 region PMID: 16585770
    18. the WASp/SNX9/p85/CD28 complex enables a unique interface of endocytic, actin polymerizing, and signal transduction pathways required for CD28-mediated T cell costimulation PMID: 17242350
    19. SNX9 is directly involved in coupling actin dynamics to achieve membrane remodeling during multiple modes of endocytosis PMID: 17609109
    20. SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. PMID: 17948057
    21. crystallization and x-ray diffraction of SNX9 PMID: 18065239
    22. SNX9 functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes PMID: 18388313
    23. Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains. PMID: 18940612

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
  • 蛋白家族：
    Sorting nexin family
  • 組織特異性：
    Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 14973

    OMIM: 605952

    KEGG: hsa:51429

    STRING: 9606.ENSP00000376024

    UniGene: Hs.191213