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SELENBP1 Monoclonal Antibody

  • 中文名稱：
    SELENBP1 Monoclonal Antibody
  • 貨號：
    CSB-MA787990
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using SELENBP1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SELENBP1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) SELENBP1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SELENBP1; Selenium Binding Protein 1; Methanethiol Oxidase; HSBP; LPSB; 56 KDa Selenium-Binding Protein; HSP56; SBP56; SP56; MTO; Epididymis Secretory Sperm Binding Protein Li 134P; Selenium-Binding Protein 1; HEL-S-134P; EC 1.8.3.4; EHMTO; SBP
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SELENBP1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    15A6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
  • 基因功能參考文獻：
    1. High anti-SBP1 is associated with infertile women with premature ovarian failure. PMID: 27965399
    2. Downregulation of selenium-binding protein 1 is associated with lung squamous cell carcinoma. PMID: 26956891
    3. cysteine 57 is a critical determinant of SBP1 function and may play a significant role in mitochondrial function. PMID: 26593911
    4. Data indicate that loss of SBP1 may play an independent contributing role in prostate cancer progression and its levels might be useful in distinguishing indolent from aggressive disease. PMID: 25993660
    5. elevated transcript expression is widespread throughout the prefrontal cortex in schizophrenia PMID: 26241353
    6. These results have revealed a novel mechanism that SELENBP1-mediated cancer inhibition is through altering lipid/glucose metabolic signaling pathways. PMID: 25974208
    7. Decreased selenium-binding protein 1 mRNA expression is associated with renal cell carcinoma. PMID: 25227434
    8. hSP56 plays an important role in regulating HIF-1alpha, which may be one of mechanisms of hSP56 expression in suppressing the malignant characteristics of prostate cancer cells. PMID: 24874852
    9. the downregulated SELENBP1 expression was reactivated by inducing differentiation. Therefore, SELENBP1 is a potential pharmacological target for individualized CRC treatment. PMID: 24737289
    10. Decreased SELENBP1 expression is an early event in lung squamous cell cancer tumorigenesis. PMID: 23977169
    11. The expression level of SELENBP1 could be an important marker for predicting survival and effectiveness of selenium supplementation in breast cancer. PMID: 23704933
    12. These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs PMID: 23483240
    13. SP1 is present in reduced levels in several cancer types as compared with normal tissues, and lower levels are associated with poor clinical prognosis. PMID: 20530237
    14. Glutathione peroxidase (GPx)-1 enzyme activity is inversely correlated with selenium binding protein (SBP)-1 levels in prostate tissue, based on the Gleason score. PMID: 22072582
    15. The suppression of Selenium-binding protein 1 may be a late event in gastric carcinogenesis. PMID: 20480265
    16. The 3-year survival rate of gastric cancer patients with high expression of selenium-binding protein 1 was significantly higher than that of patients with low expression PMID: 21497372
    17. down-regulation of SBP1 may play a key role in the tumorigenic process of human gastric carcinoma PMID: 20354826
    18. Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis. PMID: 21143902
    19. A reduced SELENBP1 expression by immunohistochemistry in liver tissues of patients with hepatocarcinoma (HCC), is reported. PMID: 21338716
    20. evidence for recurrence of decreased copy-number of the SELENBP1 locus in three unrelated schizophrenia patients' cohorts but not in controls, raising the possibility of functional involvement of these mutations in the etiology of the disease PMID: 20615253
    21. SELENBP1 expression may be an important predictor of response to chemoprevention or chemosensitization with certain forms of selenium in esophageal tissues. PMID: 20332323
    22. SBP1 has tumor suppressor functions that are inhibited in colorectal cancer through epigenetic silencing PMID: 19924303
    23. loss of selenium-binding protein 1 associated with increasing epithelial proliferation indicates selenium-binding protein 1 is involved in tumorigenesis of ovarian and micropapillary serous borderline tumor and low-grade serous carcinoma. PMID: 19896693
    24. SBP may be involved in the initial sequential events in rapid cell outgrowth, such as determining direction of cell outgrowth and recruitment of actin monomer. PMID: 15108003
    25. changes of SELENBP1 expression in malignant ovarian cancer are an indicator of aberration of selenium/androgen pathways and may reveal prognostic information of ovarian cancer PMID: 16380993
    26. Suppression of SELENBP1 is a frequent and late event in colorectal carcinogenesis, and may contribute to the rapid progression of colorectal carcinoma. PMID: 16645984
    27. Elevated SELENBP1 is a possibly consistent feature in the schizophrenic brain and this could underlie some commonalities of psychosis across the boundaries of diagnoses. PMID: 18163446
    28. Associated with differentiation of the normal colonic epithelia and may be a positive prognostic factor for survival in stage III colorectal carcinoma PMID: 18435490
    29. VDU1 was identified as a protein partner of hSP56. PMID: 19118533
    30. The genetic variation in SELENBP1 may influence risk for the disorder, while this significance did not remain when other inheritance models were considered. PMID: 19596560

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  • 亞細胞定位：
    Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Selenium-binding protein family
  • 組織特異性：
    Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated i
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10719

    OMIM: 604188

    KEGG: hsa:8991

    STRING: 9606.ENSP00000357861

    UniGene: Hs.632460