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RALB Monoclonal Antibody

  • 中文名稱：
    RALB Monoclonal Antibody
  • 貨號：
    CSB-MA909189
  • 規格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of C2C12 cells with RALB associated protein antibody. Nuclei were stained blue with DAPI; RALB associated protein was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using RALB antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with RALB antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) RALB Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    RALB; RAS Like Proto-Oncogene B; Ras Related GTP Binding Protein B; Ras-Related Protein Ral-B; V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related; GTP Binding Protein); V-Ral Simian Leukemia Viral Oncogene Homolog B; RALB Ras Like Proto-Oncogene B; RAS-Like Protein B; EC 3.6.5.2
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human RALB protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2H10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors.
  • 基因功能參考文獻：
    1. our work provides new insight into the specific roles of Ras effector pathways in acute myeloid leukemia and has identified RALB signaling as a key survival pathway PMID: 27556501
    2. High RALB expression is associated with acute myeloid leukemia. PMID: 27991934
    3. Inhibition of Ral GTPases Using a Stapled Peptide Approach. PMID: 27334922
    4. These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I. PMID: 25573158
    5. High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression. PMID: 24389431
    6. Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. PMID: 24747441
    7. nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles PMID: 24056301
    8. a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation PMID: 22331470
    9. Study finds that the Ras-like small G protein, RalB, is localized to nascent autophagosomes and is activated on nutrient deprivation. PMID: 21241894
    10. Non-phosphorylated RalB is associated with bladder cancer cell growth and metastasis. PMID: 20940393
    11. RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival; RALB is specifically required for survival of tumour cells but not normal cells PMID: 12856001
    12. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
    13. RalB was found to mediate SDF-1-induced migration PMID: 18227351
    14. Backbone dynamics and the structure of free RalB bound to the GTP analogue GMPPNP were determined using NMR spectroscopy. PMID: 19166349
    15. 1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation. Backbone amide dynamics parameters for a majority of residues have also been obtained PMID: 19636851

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數據庫鏈接：

    HGNC: 9840

    OMIM: 179551

    KEGG: hsa:5899

    STRING: 9606.ENSP00000272519

    UniGene: Hs.469820