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  4. PPP2R1B Monoclonal Antibody

PPP2R1B Monoclonal Antibody

  • 中文名稱：
    PPP2R1B Monoclonal Antibody
  • 貨號：
    CSB-MA900330
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using PPP2R1B antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PPP2R1B antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) PPP2R1B Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PPP2R1B; Protein Phosphatase 2 Scaffold Subunit Abeta; PP2A-Abeta; PR65B; Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta Isoform; Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform; Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta; Protein Phosphatase 2A, Regulatory Subunit A, Beta Isoform; Protein Phosphatase 2, Regulatory Subunit A, Beta; Protein Phosphatase 2 Regulatory Subunit A, Beta; PP2A Subunit A Isoform PR65-Beta; PP2A Subunit A Isoform R1-Beta; PP2A-A-Beta
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PPP2R1B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6F11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
  • 基因功能參考文獻(xiàn)：
    1. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730
    2. For PPP2R1B, no mutations were detected in our samples. PMID: 23588898
    3. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167
    4. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745
    5. apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831
    6. PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517
    7. Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019
    8. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501
    9. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570
    10. PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
    11. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176

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  • 蛋白家族：
    Phosphatase 2A regulatory subunit A family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9303

    OMIM: 603113

    KEGG: hsa:5519

    STRING: 9606.ENSP00000311344

    UniGene: Hs.269128