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  4. PFKP Monoclonal Antibody

PFKP Monoclonal Antibody

  • 中文名稱：
    PFKP Monoclonal Antibody
  • 貨號：
    CSB-MA145733
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of PFKP expression in HepG2 cells using PFKP antibody. Green, isotype control; red, PFKP.
    • Immunocytochemical staining of HepG2 cells with PFKP antibody. Nuclei were stained blue with DAPI; PFKP was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using PFKP antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PFKP antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) PFKP Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PFKP; Phosphofructokinase, Platelet; PFK-C; PFKF; ATP-Dependent 6-Phosphofructokinase, Platelet Type; Phosphofructo-1-Kinase Isozyme C; 6-Phosphofructokinase Type C; Phosphohexokinase; EC 2.7.1.11; ATP-PFK; PFK-P; 6-Phosphofructokinase, Platelet Type; Phosphofructokinase, Platelet Type; Phosphofructokinase 1; EC 2.7.1
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PFKP protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1H1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  • 基因功能參考文獻：
    1. Snail functions as a metabolic switch between aerobic glycolysis and pentose phosphate pathway by repressing PFKP, a cancer-specific PFK-1, allowing cancer cell survival under metabolic stress. PMID: 28176759
    2. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386. PMID: 29038421
    3. Data indicate that platelet isoform of phosphofructokinase (PFKP) not only is required for metabolic reprogramming and maintaining cell proliferation, but also may be a valid target for anti-renal cancer pharmaceutical agents. PMID: 27049827
    4. The crystallized PFKP is permanently activated by a deletion of the 22 C-terminal residues. PMID: 26205495
    5. Anti-human protein S antibody induces tissue factor expression through a direct interaction with PFKP and ERK1/2 activation in coronary artery endothelial cells. PMID: 24331211
    6. expression of TARDBP is significantly elevated in HCC and it regulates the expression of PFKP, the rate-limiting enzyme for glycolysis, through negative regulation of microRNA 520s (miR-520s). PMID: 23389994
    7. KLF4 plays a role in maintenance of high glycolytic metabolism by transcriptional activation of the PFKP gene in breast cancer cells. PMID: 21586797
    8. PFKP was identified using a trifunctional phenyl sulfonate probe. PMID: 12438565
    9. The transcription start point was determined at 48 bp upstream of the start codon. the region -65 to +48 turned out to be sufficient for promoter activity PMID: 15716112
    10. PFKP polymorphisms play no apparent role in the development of common forms of obesity in the Danish population. PMID: 18682847

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade "E" sub-subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8878

    OMIM: 171840

    KEGG: hsa:5214

    STRING: 9606.ENSP00000370517

    UniGene: Hs.26010